ID   HXB3A_TAKRU             Reviewed;         474 AA.
AC   Q1KKX7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Homeobox protein Hox-B3a;
GN   Name=hoxb3a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481665; ABF22417.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1KKX7; -.
DR   SMR; Q1KKX7; -.
DR   STRING; 31033.ENSTRUP00000024389; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; Q1KKX7; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..474
FT                   /note="Homeobox protein Hox-B3a"
FT                   /id="PRO_0000265978"
FT   DNA_BIND        212..271
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          91..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           168..173
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        117..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  49855 MW;  F8AF9FEF8D2E1B28 CRC64;
     MQKTTYYDNS STLFGGYSSY QVQGAAAAAA NGFGGYDAPV PVSHHQPAFQ SATHLDVDSY
     QRSACSLQSL GSTNSHQQQQ QLAKTKELNG SCMRSSLPPE HHPSSQVSPP LPPNPTNGNS
     GAQQPGGSAG TSSKSGSNKS STSSSSISSS TSSSSSSLPP NPTLAKQIFP WMKECRQTTK
     QKTCSPSNNS GNGAESGSSG EKSPTGGSSA SSKRARTAYT SAQLVELEKE FHFNRYLCRP
     RRVEMANLLN LSERQIKIWF QNRRMKYKKD QKSKGLSSSS GGPSPTGSPP LTMQSSASYL
     NSMHPMGGGG GYDVPSPPSF GKPHQGVSYA MSTAYSNVPV KGCPPQQKYG PPDPDYGDPH
     PHHSLVQANS AGYGTPTNMQ GSPVYVGGGS YLEPMPGSGP SMYGLNHLGP TPTHHQTMDY
     NGAGPMSATN QHHVGGGGPP GPCDPPTHPT YTELSAHHTS SQGRIQEAPK LTHL