ID   HXB3_CHICK              Reviewed;         399 AA.
AC   P23682;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Homeobox protein Hox-B3;
DE   AltName: Full=Homeobox protein Hox-2.7;
DE            Short=Chox-2.7;
GN   Name=HOXB3; Synonyms=CHOX-2.7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Comet Hubbard hybrid;
RX   PubMed=7959024; DOI=10.1016/0378-1119(94)90183-x;
RA   Rex M., Scotting P.J.;
RT   "Chick HoxB3: deduced amino-acid sequence and embryonic gene expression.";
RL   Gene 149:381-382(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 128-223.
RX   PubMed=1973835; DOI=10.1093/nar/18.13.3999;
RA   Scotting P.J., Hewitt M., Keynes R.J.;
RT   "Isolation and analysis of chick homeobox cDNA clones.";
RL   Nucleic Acids Res. 18:3999-3999(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X74506; CAA52613.1; -; Genomic_DNA.
DR   EMBL; X52749; CAB57800.1; -; mRNA.
DR   PIR; S10885; S10885.
DR   PIR; S71480; S71480.
DR   AlphaFoldDB; P23682; -.
DR   SMR; P23682; -.
DR   PaxDb; P23682; -.
DR   VEuPathDB; HostDB:geneid_395502; -.
DR   InParanoid; P23682; -.
DR   PhylomeDB; P23682; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..399
FT                   /note="Homeobox protein Hox-B3"
FT                   /id="PRO_0000200119"
FT   DNA_BIND        159..218
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          18..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           124..129
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        18..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        218
FT                   /note="Q -> E (in Ref. 2; CAB57800)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   399 AA;  43504 MW;  F5C2F2FC289BE3A6 CRC64;
     MQKTTYYESS TLFGGYSYGS TNGFGYEGPQ QPFQPGSHVE NDFQRSACSL QSLGNTTQHA
     KSKDLNGSCM RPSLPQEHHP PPTVSPPPNP TTNSTSSNSI PSGSAKVPRV KPTSVQTPSL
     TKQIFPWMKE SRQNSKQKSS SPSTETCSGE KTPPGSSASK RARTAYTSAQ LVELEKEFHF
     NRYLCRPRRV EMANLLNLSE RQIKIWFQNR RMKYKKDQKS KGMGSSSGGP SPTGSPPQPM
     QSSAGFMNAL HTMSSNYDAP SPPSLNKPHQ NAYAHVTNYQ NPIKGALQQK YTNTAPEYDP
     HVLQGNGVAY GTPSMQGSPV YVGGNYVDSL PTSGPSLYGL NHLPHHQAAN MDYSGPPQMP
     PSQHHGPCEP HPTYTDLWPA QPTHLLGGQN PGGPKLTHL