HXB3_MOUSE
ID HXB3_MOUSE Reviewed; 433 AA.
AC P09026; P10285; Q4PJ06; Q61680;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 4.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Homeobox protein Hox-B3;
DE AltName: Full=Homeobox protein Hox-2.7;
DE AltName: Full=Homeobox protein MH-23;
GN Name=Hoxb3; Synonyms=Hox-2.7, Hoxb-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1582411; DOI=10.1002/j.1460-2075.1992.tb05234.x;
RA Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E.,
RA Krumlauf R.;
RT "Analysis of the murine Hox-2.7 gene: conserved alternative transcripts
RT with differential distributions in the nervous system and the potential for
RT shared regulatory regions.";
RL EMBO J. 11:1825-1836(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7890121; DOI=10.1016/0020-711x(94)90184-8;
RA Brown W.M., Taylor G.R.;
RT "The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain
RT multiple transcription-regulatory elements.";
RL Int. J. Biochem. 26:1403-1409(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-361.
RX PubMed=2890503; DOI=10.1089/dna.1987.6.409;
RA Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.;
RT "New murine homeoboxes: structure, chromosomal assignment, and differential
RT expression in adult erythropoiesis.";
RL DNA 6:409-418(1987).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 181-265.
RX PubMed=2463210; DOI=10.1101/gad.2.11.1424;
RA Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D.,
RA Krumlauf R.;
RT "Characterization of a murine homeo box gene, Hox-2.6, related to the
RT Drosophila Deformed gene.";
RL Genes Dev. 2:1424-1438(1988).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X66177; CAA46951.1; -; mRNA.
DR EMBL; S35628; AAA08719.1; -; mRNA.
DR EMBL; U02278; AAB60496.1; -; Genomic_DNA.
DR EMBL; M18168; AAA37840.1; -; Genomic_DNA.
DR CCDS; CCDS25299.1; -.
DR PIR; S20963; S20963.
DR RefSeq; NP_001073338.1; NM_001079869.1.
DR RefSeq; NP_034588.2; NM_010458.2.
DR RefSeq; XP_006532346.1; XM_006532283.3.
DR RefSeq; XP_006532347.1; XM_006532284.3.
DR RefSeq; XP_006532348.1; XM_006532285.3.
DR RefSeq; XP_006532349.1; XM_006532286.3.
DR RefSeq; XP_006532351.1; XM_006532288.1.
DR RefSeq; XP_006532352.1; XM_006532289.3.
DR RefSeq; XP_006532353.1; XM_006532290.3.
DR RefSeq; XP_011247059.1; XM_011248757.2.
DR AlphaFoldDB; P09026; -.
DR SMR; P09026; -.
DR STRING; 10090.ENSMUSP00000091476; -.
DR iPTMnet; P09026; -.
DR PhosphoSitePlus; P09026; -.
DR PaxDb; P09026; -.
DR PRIDE; P09026; -.
DR ProteomicsDB; 267022; -.
DR Antibodypedia; 4079; 154 antibodies from 23 providers.
DR DNASU; 15410; -.
DR Ensembl; ENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
DR Ensembl; ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
DR GeneID; 15410; -.
DR KEGG; mmu:15410; -.
DR UCSC; uc007lbw.1; mouse.
DR CTD; 3213; -.
DR MGI; MGI:96184; Hoxb3.
DR VEuPathDB; HostDB:ENSMUSG00000048763; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159774; -.
DR HOGENOM; CLU_051508_1_0_1; -.
DR InParanoid; P09026; -.
DR OMA; PPLKGCA; -.
DR OrthoDB; 934469at2759; -.
DR PhylomeDB; P09026; -.
DR TreeFam; TF315938; -.
DR BioGRID-ORCS; 15410; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Hoxb3; mouse.
DR PRO; PR:P09026; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09026; protein.
DR Bgee; ENSMUSG00000048763; Expressed in vertebra pre-cartilage condensation and 162 other tissues.
DR ExpressionAtlas; P09026; baseline and differential.
DR Genevisible; P09026; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0051216; P:cartilage development; IGI:MGI.
DR GO; GO:0060216; P:definitive hemopoiesis; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0060324; P:face development; IDA:MGI.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IGI:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0050767; P:regulation of neurogenesis; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021546; P:rhombomere development; IDA:MGI.
DR GO; GO:0030878; P:thyroid gland development; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..433
FT /note="Homeobox protein Hox-B3"
FT /id="PRO_0000200118"
FT DNA_BIND 191..250
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 63..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 129..134
FT /note="Antp-type hexapeptide"
FT COMPBIAS 79..94
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 113
FT /note="G -> C (in Ref. 1; CAA46951/AAA08719)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="A -> S (in Ref. 1; CAA46951/AAA08719)"
FT /evidence="ECO:0000305"
FT CONFLICT 152..168
FT /note="GCGGGGGGGGGGGGGGG -> RLWWWRPAVVAAAAAVR (in Ref. 3;
FT AAA37840)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="D -> N (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 216..217
FT /note="LC -> FV (in Ref. 3; AAA37840)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="S -> L (in Ref. 3; AAA37840)"
FT /evidence="ECO:0000305"
FT CONFLICT 342..361
FT /note="GAYGTPTMQGSPVYVGGGGY -> APTGRPPCRAVRCMWAGVAT (in
FT Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 433 AA; 44353 MW; 9AD3C922663612A6 CRC64;
MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS ACSLQSLGNA
APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT SNSNNGGGPS KSGPPKCGAG
SNSTLTKQIF PWMKESRQTS KLKNSSPGTA EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG
GDKSPPGSAA SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ
NRRMKYKKDQ KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG
HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ GSPVYVGGGG
YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH HGPCDPHPTY TDLSSHHAPP
QGRIQEAPKL THL
