HXB4A_DANRE
ID HXB4A_DANRE Reviewed; 246 AA.
AC P22574; O42369; Q8AWY6; Q9PWL9;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Homeobox protein Hox-B4a;
DE Short=Hox-B4;
DE AltName: Full=Homeobox protein Zf-13;
GN Name=hoxb4a; Synonyms=hox-b4, hoxb4, zf13;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-227.
RX PubMed=2468579; DOI=10.1016/0378-1119(88)90310-1;
RA Njoelstad P.R., Molven A., Eiken H.G., Fjose A.;
RT "Structure and neural expression of a zebrafish homeobox sequence.";
RL Gene 73:33-46(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 185-246, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425135; DOI=10.1242/dev.125.3.393;
RA Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.;
RT "Zebrafish hox genes: expression in the hindbrain region of wild-type and
RT mutants of the segmentation gene, valentino.";
RL Development 125:393-406(1998).
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: First expressed at the 1-somite stage with an
CC anterior expression limit in rhombomere 7 (r7) of the developing
CC hindbrain. By the 15-somite stage, the anterior expression limit is at
CC the r6/r7 boundary and this is maintained until at least 30 hours of
CC development. At the 10-somite stage, weakly expressed in the paraxial
CC mesoderm with an anterior expression limit at somite 1.
CC {ECO:0000269|PubMed:9425135, ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA56866.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD59115.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF071252; AAD15945.1; -; Genomic_DNA.
DR EMBL; AL645782; CAD59115.1; ALT_INIT; Genomic_DNA.
DR EMBL; M24085; AAA56866.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Y13946; CAA74284.1; -; mRNA.
DR PIR; JT0489; JT0489.
DR RefSeq; NP_571193.1; NM_131118.1.
DR AlphaFoldDB; P22574; -.
DR SMR; P22574; -.
DR STRING; 7955.ENSDARP00000008458; -.
DR PaxDb; P22574; -.
DR Ensembl; ENSDART00000012470; ENSDARP00000008458; ENSDARG00000013533.
DR GeneID; 30340; -.
DR KEGG; dre:30340; -.
DR CTD; 30340; -.
DR ZFIN; ZDB-GENE-990415-105; hoxb4a.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000162072; -.
DR HOGENOM; CLU_061398_0_0_1; -.
DR InParanoid; P22574; -.
DR OMA; FGRRSAC; -.
DR PhylomeDB; P22574; -.
DR TreeFam; TF352857; -.
DR PRO; PR:P22574; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000013533; Expressed in presumptive rhombomere 7 and 39 other tissues.
DR ExpressionAtlas; P22574; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..246
FT /note="Homeobox protein Hox-B4a"
FT /id="PRO_0000200125"
FT DNA_BIND 151..210
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 23..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 130..135
FT /note="Antp-type hexapeptide"
FT COMPBIAS 26..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 27704 MW; C1A695D6291A18F9 CRC64;
MAMSSYLINS NYVDPKFPPC EEYSQSDYLP SHSPDYYSAQ RQDPSFQHES IYHQRSGCAD
PPYSSCQGPG QPAAVISPRG HVLPTTALST PLPEPSHHCD SVTPSPPPAC GQTPTSQNTS
TVSSRKDPVV YPWMKKVHVN IVSPNYSGGE PKRSRTAYTR QQVLELEKEF HYNRYLTRRR
RVEIAHTLCL SERQIKIWFQ NRRMKWKKDH KLPNTKIRSN SASTNSSGCP TLCSNQSRAS
GPPPSL
