ID   HXB4_CHICK              Reviewed;         245 AA.
AC   P14840;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Homeobox protein Hox-B4;
DE   AltName: Full=Homeobox protein Hox-Z;
DE            Short=Chox-Z;
GN   Name=HOXB4; Synonyms=CHOX-Z;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1968620; DOI=10.1093/nar/18.1.184;
RA   Sasaki H., Kuroiwa A.;
RT   "The nucleotide sequence of the cDNA encoding a chicken Deformed family
RT   homeobox gene, Chox-Z.";
RL   Nucleic Acids Res. 18:184-184(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X17612; CAA35614.1; -; mRNA.
DR   PIR; S10092; S10092.
DR   RefSeq; NP_990624.1; NM_205293.1.
DR   AlphaFoldDB; P14840; -.
DR   SMR; P14840; -.
DR   STRING; 9031.ENSGALP00000000372; -.
DR   PaxDb; P14840; -.
DR   Ensembl; ENSGALT00000000373; ENSGALP00000000372; ENSGALG00000000284.
DR   Ensembl; ENSGALT00000104768; ENSGALP00000073243; ENSGALG00000000284.
DR   GeneID; 396230; -.
DR   KEGG; gga:396230; -.
DR   CTD; 3214; -.
DR   VEuPathDB; HostDB:geneid_396230; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000162072; -.
DR   InParanoid; P14840; -.
DR   OMA; QRRETTF; -.
DR   OrthoDB; 1154159at2759; -.
DR   PhylomeDB; P14840; -.
DR   PRO; PR:P14840; -.
DR   Proteomes; UP000000539; Chromosome 27.
DR   Bgee; ENSGALG00000000284; Expressed in ovary and 10 other tissues.
DR   ExpressionAtlas; P14840; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Homeobox protein Hox-B4"
FT                   /id="PRO_0000200124"
FT   DNA_BIND        150..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          31..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           129..134
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        215..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  27782 MW;  4949B200FEC44E91 CRC64;
     MAMSSFLINS NYVDPKFPPC EEYSHSDYLP NHSPEYYSSQ RRESTFQHEA MYQPRSACSE
     QLYPSCQSSG HQAAVLSPRG HVHPPAGLQS HLSEPNHPCE PGTPSPPPSC SQNSLNQSPS
     NSSCKEPVVY PWMKKVHVST VNPNYSGGEP KRSRTAYTRQ QVLELEKEFH YNRYLTRRRR
     VEIAHSLCLS ERQIKIWFQN RRMKWKKDHK LPNTKIRSNP SSSSASLQIP PAASQSRSSG
     PASSL