HXB5B_DANRE
ID HXB5B_DANRE Reviewed; 276 AA.
AC P09013; O57359; Q4PR96; Q6DC10; Q8JH53; Q9PWM0;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Homeobox protein Hox-B5b;
DE AltName: Full=Homeobox protein Zf-54;
DE AltName: Full=Hox-B5-like;
GN Name=hoxb5b; Synonyms=zf54; ORFNames=zgc:101134;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 101-203.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-276.
RX PubMed=2902580; DOI=10.1093/nar/16.19.9097;
RA Njolstad P.R., Molven A., Hordvik I., Apold J., Fjose A.;
RT "Primary structure, developmentally regulated expression and potential
RT duplication of the zebrafish homeobox gene ZF-21.";
RL Nucleic Acids Res. 16:9097-9111(1988).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 234-276, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: At the 10-somite stage, barely detectable in the
CC paraxial mesoderm. At the 20-somite stage, expressed within the
CC developing CNS with an anterior expression limit at somite 1.
CC {ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AF071253; AAD15946.1; -; Genomic_DNA.
DR EMBL; AL645798; CAD44458.1; -; Genomic_DNA.
DR EMBL; BC078285; AAH78285.1; -; mRNA.
DR EMBL; DQ060547; AAY67925.1; -; mRNA.
DR EMBL; X12803; CAA31291.1; -; Genomic_DNA.
DR EMBL; Y14526; CAA74861.1; -; mRNA.
DR RefSeq; NP_571612.2; NM_131537.3.
DR AlphaFoldDB; P09013; -.
DR SMR; P09013; -.
DR STRING; 7955.ENSDARP00000070639; -.
DR PaxDb; P09013; -.
DR GeneID; 58052; -.
DR KEGG; dre:58052; -.
DR CTD; 58052; -.
DR ZFIN; ZDB-GENE-000823-6; hoxb5b.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P09013; -.
DR OrthoDB; 980936at2759; -.
DR PhylomeDB; P09013; -.
DR TreeFam; TF316310; -.
DR PRO; PR:P09013; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
DR GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR GO; GO:0007507; P:heart development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..276
FT /note="Homeobox protein Hox-B5b"
FT /id="PRO_0000200133"
FT DNA_BIND 201..260
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 63..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 183..188
FT /note="Antp-type hexapeptide"
FT COMPBIAS 71..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 47
FT /note="Y -> N (in Ref. 1; AAD15946)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="H -> R (in Ref. 3 and 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="G -> K (in Ref. 5; CAA31291)"
FT /evidence="ECO:0000305"
FT CONFLICT 201..202
FT /note="GK -> EN (in Ref. 5; CAA31291)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="T -> A (in Ref. 5; CAA31291)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="A -> R (in Ref. 5; CAA31291)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 30912 MW; 07BD5B28FFEECFE6 CRC64;
MSSYFLNSFS GRYPNGSDYQ LLNYGTNGAM NASYRDSTSM HSGSFGYNYN GIDLSVNRPN
NGHFGAVGDN SRAFQNPSQE TRYRQSSCSL SSPDPLSCAT SDTLELKGSS PPSDQSTPTG
NSRLTNSNNL TSSNSTHFAD TDETNVSSET EEGAQTTTTS HTQKQESVAT STTTPNDGQT
PQIFPWMRKL HISHDMTGPD GKRARTAYTR YQTLELEKEF HFNRYLTRRR RIEIAHALCL
SERQIKIWFQ NRRMKWKKDN KLKSMSLATA GSAFQN
