ID   HXB5_CHICK              Reviewed;          82 AA.
AC   P14838;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Homeobox protein Hox-B5;
DE   AltName: Full=Homeobox protein Hox-2.1;
DE            Short=Ghox-2.1;
DE   Flags: Fragment;
GN   Name=HOXB5; Synonyms=GHOX-2.1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Erythrocyte;
RX   PubMed=2575515; DOI=10.1242/dev.105.3.639;
RA   Wedden S.E., Pang K., Eichele G.;
RT   "Expression pattern of homeobox-containing genes during chick
RT   embryogenesis.";
RL   Development 105:639-650(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X16846; CAA34743.1; -; Genomic_DNA.
DR   PIR; S08302; S08302.
DR   AlphaFoldDB; P14838; -.
DR   SMR; P14838; -.
DR   STRING; 9031.ENSGALP00000042679; -.
DR   PaxDb; P14838; -.
DR   VEuPathDB; HostDB:geneid_425096; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_061398_2_1_1; -.
DR   InParanoid; P14838; -.
DR   PhylomeDB; P14838; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..82
FT                   /note="Homeobox protein Hox-B5"
FT                   /id="PRO_0000200131"
FT   DNA_BIND        7..66
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
SQ   SEQUENCE   82 AA;  9877 MW;  53F70ACDC9FDEF8F CRC64;
     DMTGPDGKRA RTAYTRYQTL ELEKEFHFNR YLTRRRRIEI AHALCLSERQ IKIWFQNRRM
     KWKKDNKLKS MSLASAGSAF QP