HXB5_MOUSE
ID HXB5_MOUSE Reviewed; 269 AA.
AC P09079; Q3ZAY8;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Homeobox protein Hox-B5;
DE AltName: Full=Homeobox protein H24.1;
DE AltName: Full=Homeobox protein Hox-2.1;
DE AltName: Full=Homeobox protein Mu-1;
GN Name=Hoxb5; Synonyms=Hox-2.1, Hoxb-5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=2889591; DOI=10.1242/dev.99.4.603;
RA Krumlauf R., Holland P.W.H., McVey J.H., Hogan B.L.M.;
RT "Developmental and spatial patterns of expression of the mouse homeobox
RT gene, Hox 2.1.";
RL Development 99:603-617(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
RA Arnold J.M.;
RT "Studies on the Hox-B5 gene.";
RL Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-259.
RX PubMed=4058581; DOI=10.1038/317745a0;
RA Jackson I.J., Schofield P., Hogan B.L.M.;
RT "A mouse homoeo box gene is expressed during embryogenesis and in adult
RT kidney.";
RL Nature 317:745-748(1985).
RN [6]
RP NUCLEOTIDE SEQUENCE OF 194-269.
RX PubMed=4075393; DOI=10.1016/0092-8674(85)90008-x;
RA Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.;
RT "Expression of homologous homeo-box-containing genes in differentiated
RT human teratocarcinoma cells and mouse embryos.";
RL Cell 43:19-28(1985).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P09079; O35317: Pbx3; NbExp=2; IntAct=EBI-26671239, EBI-26671189;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in a broad spectrum of tissues.
CC -!- DEVELOPMENTAL STAGE: Embryo.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; M26283; AAA37842.1; -; mRNA.
DR EMBL; AK133512; BAE21695.1; -; mRNA.
DR EMBL; BC103595; AAI03596.1; -; mRNA.
DR EMBL; BC103596; AAI03597.1; -; mRNA.
DR EMBL; BC103604; AAI03605.1; -; mRNA.
DR EMBL; BC103607; AAI03608.1; -; mRNA.
DR EMBL; L36070; AAA50294.1; -; Genomic_DNA.
DR EMBL; X03033; CAB57812.1; -; Genomic_DNA.
DR CCDS; CCDS25296.1; -.
DR PIR; A43551; A43551.
DR PIR; B24777; B24777.
DR RefSeq; NP_032294.2; NM_008268.2.
DR AlphaFoldDB; P09079; -.
DR SMR; P09079; -.
DR BioGRID; 200379; 1.
DR IntAct; P09079; 1.
DR STRING; 10090.ENSMUSP00000035423; -.
DR iPTMnet; P09079; -.
DR PhosphoSitePlus; P09079; -.
DR MaxQB; P09079; -.
DR PaxDb; P09079; -.
DR PRIDE; P09079; -.
DR ProteomicsDB; 273287; -.
DR Antibodypedia; 17850; 237 antibodies from 30 providers.
DR DNASU; 15413; -.
DR Ensembl; ENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
DR GeneID; 15413; -.
DR KEGG; mmu:15413; -.
DR UCSC; uc007lbu.2; mouse.
DR CTD; 3215; -.
DR MGI; MGI:96186; Hoxb5.
DR VEuPathDB; HostDB:ENSMUSG00000038700; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000158354; -.
DR HOGENOM; CLU_061398_2_1_1; -.
DR InParanoid; P09079; -.
DR OMA; TEGQTPQ; -.
DR OrthoDB; 980936at2759; -.
DR PhylomeDB; P09079; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15413; 5 hits in 80 CRISPR screens.
DR PRO; PR:P09079; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09079; protein.
DR Bgee; ENSMUSG00000038700; Expressed in inferior vagus X ganglion and 123 other tissues.
DR Genevisible; P09079; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0045446; P:endothelial cell differentiation; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..269
FT /note="Homeobox protein Hox-B5"
FT /id="PRO_0000200129"
FT DNA_BIND 194..253
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 75..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 176..181
FT /note="Antp-type hexapeptide"
FT COMPBIAS 83..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 81
FT /note="Q -> K (in Ref. 1; AAA37842)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 29464 MW; B3508345236FB6A8 CRC64;
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS
ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ
ATPASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM
RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI
WFQNRRMKWK KDNKLKSMSL ATAGSAFQP
