ID   HXB6A_DANRE             Reviewed;         228 AA.
AC   P15861; Q4PRA2; Q8AWY8;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Homeobox protein Hox-B6a;
DE            Short=Hox-B6;
DE   AltName: Full=Homeobox protein Zf-22;
GN   Name=hoxb6a; Synonyms=hox-b6, hoxb6, zf22;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=1968004; DOI=10.1002/j.1460-2075.1990.tb08138.x;
RA   Njolstad P.R., Molven A., Apold J., Fjose A.;
RT   "The zebrafish homeobox gene hox-2.2: transcription unit, potential
RT   regulatory regions and in situ localization of transcripts.";
RL   EMBO J. 9:515-524(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8097929; DOI=10.1016/0167-4781(93)90253-a;
RA   Molven A., Hordvik I., Njolstad P.R.;
RT   "Sequence analysis of the zebrafish hox-B5/B6 region.";
RL   Biochim. Biophys. Acta 1173:102-106(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 54-153.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [5]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: At the 10-somite stage, expressed in the paraxial
CC       mesoderm with an anterior expression limit at somite 4. At the 20-
CC       somite stage, expressed in the developing CNS with an anterior
CC       expression limit adjacent to the somite 1/somite 2 boundary, and also
CC       expressed in the presumptive pronephric ducts.
CC       {ECO:0000269|PubMed:9425136}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X17267; CAA35171.1; -; Genomic_DNA.
DR   EMBL; X68248; CAA48319.1; -; Genomic_DNA.
DR   EMBL; AL645782; CAD59113.1; -; Genomic_DNA.
DR   EMBL; DQ060541; AAY67919.1; -; mRNA.
DR   PIR; S32563; S32563.
DR   RefSeq; NP_571194.1; NM_131119.1.
DR   AlphaFoldDB; P15861; -.
DR   BMRB; P15861; -.
DR   SMR; P15861; -.
DR   STRING; 7955.ENSDARP00000002263; -.
DR   PaxDb; P15861; -.
DR   GeneID; 30341; -.
DR   KEGG; dre:30341; -.
DR   CTD; 30341; -.
DR   ZFIN; ZDB-GENE-990415-106; hoxb6a.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P15861; -.
DR   OrthoDB; 1186205at2759; -.
DR   PhylomeDB; P15861; -.
DR   PRO; PR:P15861; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..228
FT                   /note="Homeobox protein Hox-B6a"
FT                   /id="PRO_0000200138"
FT   DNA_BIND        150..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           132..137
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        6
FT                   /note="L -> V (in Ref. 3; CAD59113)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   228 AA;  26088 MW;  4AC1B6C545B8668D CRC64;
     MSSYFLNSTF PVTLPGGQES FLGQIPLYSS GYTDPLRHYP GAAYGGSSVQ EKAYPSSFYQ
     QANGAYSRAT AAGPCDYATA SFYREKDPAC ALASIEEHSF VLSQDHRKTD CTGSTGKSIY
     PEADEQKPSA PVYPWMQRMN SCNGTFGNAG RRGRQTYTRY QTLELEKEFH FNRYLTRRRR
     IEIAHALCLT ERQIKIWFQN RRMKWKKENK LINCSQTSGE EEEEKRTE