HXB6_MOUSE
ID HXB6_MOUSE Reviewed; 224 AA.
AC P09023;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Homeobox protein Hox-B6;
DE AltName: Full=Homeobox protein Hox-2.2;
DE AltName: Full=Homeobox protein MH-22A;
GN Name=Hoxb6; Synonyms=Hox-2.2, Hoxb-6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2899893; DOI=10.1073/pnas.85.15.5582;
RA Schughart K., Utset M.F., Awgulewitsch A., Ruddle F.H.;
RT "Structure and expression of Hox-2.2, a murine homeobox-containing gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:5582-5586(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1672751; DOI=10.1093/nar/19.3.539;
RA Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.;
RT "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic
RT cells and murine embryonic and adult tissues.";
RL Nucleic Acids Res. 19:539-545(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-224.
RX PubMed=2890503; DOI=10.1089/dna.1987.6.409;
RA Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.;
RT "New murine homeoboxes: structure, chromosomal assignment, and differential
RT expression in adult erythropoiesis.";
RL DNA 6:409-418(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 140-224.
RX PubMed=2891608; DOI=10.1016/0888-7543(87)90011-5;
RA Hart C.P., Fainsod A., Ruddle F.H.;
RT "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes:
RT evolutionary and structural comparisons.";
RL Genomics 1:182-195(1987).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P09023; P41778: Pbx1; NbExp=2; IntAct=EBI-15992861, EBI-6996259;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; M18166; AAA37844.1; -; Genomic_DNA.
DR EMBL; X56459; CAA39834.1; -; mRNA.
DR EMBL; BC016893; AAH16893.1; -; mRNA.
DR EMBL; M18401; AAC27130.1; ALT_SEQ; Genomic_DNA.
DR EMBL; J03782; AAA37843.1; -; Genomic_DNA.
DR CCDS; CCDS25295.1; -.
DR PIR; A31324; A31324.
DR PIR; B29585; B29585.
DR PIR; C27176; C27176.
DR RefSeq; NP_032295.1; NM_008269.1.
DR AlphaFoldDB; P09023; -.
DR SMR; P09023; -.
DR BioGRID; 200380; 1.
DR DIP; DIP-59870N; -.
DR IntAct; P09023; 1.
DR STRING; 10090.ENSMUSP00000133281; -.
DR iPTMnet; P09023; -.
DR PhosphoSitePlus; P09023; -.
DR MaxQB; P09023; -.
DR PaxDb; P09023; -.
DR PeptideAtlas; P09023; -.
DR PRIDE; P09023; -.
DR ProteomicsDB; 273059; -.
DR Antibodypedia; 17852; 163 antibodies from 23 providers.
DR DNASU; 15414; -.
DR Ensembl; ENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690.
DR Ensembl; ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690.
DR GeneID; 15414; -.
DR KEGG; mmu:15414; -.
DR UCSC; uc007lbt.1; mouse.
DR CTD; 3216; -.
DR MGI; MGI:96187; Hoxb6.
DR VEuPathDB; HostDB:ENSMUSG00000000690; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161108; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P09023; -.
DR OMA; HYPATYG; -.
DR OrthoDB; 1186205at2759; -.
DR PhylomeDB; P09023; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15414; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Hoxb6; mouse.
DR PRO; PR:P09023; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09023; protein.
DR Bgee; ENSMUSG00000000690; Expressed in thoracic region of vertebral column and 124 other tissues.
DR Genevisible; P09023; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0034101; P:erythrocyte homeostasis; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..224
FT /note="Homeobox protein Hox-B6"
FT /id="PRO_0000200136"
FT DNA_BIND 146..205
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT MOTIF 127..132
FT /note="Antp-type hexapeptide"
FT MOD_RES 214
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 186
FT /note="T -> P (in Ref. 4; AAA37844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 25310 MW; E8FC0BDEB57F5C3D CRC64;
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFAASSYYP
PAGGGYGRAA PCDYGPAPAF YREKDAACAL SGADEPPPFH PEPRKSDCAQ DKSVFGETEE
QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA
HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KPAE
