ID   HXB7A_XENLA             Reviewed;         220 AA.
AC   Q91771; Q6DCN5;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Homeobox protein Hox-B7-A;
DE   AltName: Full=MM3;
DE   AltName: Full=XlHbox-2 A;
GN   Name=hoxb7-a; Synonyms=hbox2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2563247; DOI=10.1016/s0012-1606(89)80029-6;
RA   Fritz A.F., Cho K.W.Y., Wright C.V.E., Jegalian B.G., De Robertis E.M.;
RT   "Duplicated homeobox genes in Xenopus.";
RL   Dev. Biol. 131:584-588(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 133-220.
RX   PubMed=6207937; DOI=10.1016/0092-8674(84)90201-0;
RA   Mueller M.M., Carrasco A.E., De Robertis E.M.;
RT   "A homeo-box-containing gene expressed during oogenesis in Xenopus.";
RL   Cell 39:157-162(1984).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Maternally expressed in oocytes.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M23916; AAA49754.1; -; mRNA.
DR   EMBL; BC077970; AAH77970.1; -; mRNA.
DR   EMBL; K02616; AAA49749.1; -; Genomic_DNA.
DR   PIR; A03317; A03317.
DR   PIR; A37371; A37371.
DR   RefSeq; NP_001079110.1; NM_001085641.1.
DR   AlphaFoldDB; Q91771; -.
DR   SMR; Q91771; -.
DR   DNASU; 373643; -.
DR   GeneID; 373643; -.
DR   KEGG; xla:373643; -.
DR   CTD; 373643; -.
DR   Xenbase; XB-GENE-5959297; hoxb7.S.
DR   OMA; LSMMCPG; -.
DR   OrthoDB; 1203627at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 373643; Expressed in neurula embryo and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..220
FT                   /note="Homeobox protein Hox-B7-A"
FT                   /id="PRO_0000200146"
FT   DNA_BIND        140..199
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          197..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           129..134
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        133..135
FT                   /note="MRS -> LSL (in Ref. 3; AAA49749)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   220 AA;  24982 MW;  A55A862445E41ABD CRC64;
     MSSLYYANAL FSKYPTATSV FSSGVFPEQT SCAFASNPQR SGYGSSPGGT FPAGSAAHGL
     YSNGSSLHPQ SPAMYPSSYG LDAASFNMHC SPFEQNLSSL MCAGDPTKQN SAKAEQRESE
     LHNEANLRIY PWMRSAGADR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHVLCLT
     ERQIKIWFQN RRMKWKKENK ASSPSSNSQE KQETEEEEEE