HXB7B_XENLA
ID HXB7B_XENLA Reviewed; 220 AA.
AC P04476; P09018;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Homeobox protein Hox-B7-B;
DE AltName: Full=P52;
DE AltName: Full=XlHbox-2 B;
GN Name=hoxb7-b; Synonyms=hbox2-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2894983; DOI=10.1002/j.1460-2075.1987.tb02754.x;
RA Wright C.V.E., Cho K.W.Y., Fritz A., Buerglin T.R., De Robertis E.M.;
RT "A Xenopus laevis gene encodes both homeobox-containing and homeobox-less
RT transcripts.";
RL EMBO J. 6:4083-4094(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-220.
RX PubMed=2894634; DOI=10.1093/nar/16.4.1453;
RA Fritz A., De Robertis E.M.;
RT "Xenopus homeobox-containing cDNAs expressed in early development.";
RL Nucleic Acids Res. 16:1453-1469(1988).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P04476-1; Sequence=Displayed;
CC Name=2; Synonyms=Homeobox-less;
CC IsoId=P04476-2; Sequence=VSP_002390, VSP_002391;
CC -!- DEVELOPMENTAL STAGE: Maternally expressed in oocytes.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X07102; CAA30123.1; -; mRNA.
DR EMBL; X06592; CAA29814.1; -; mRNA.
DR EMBL; X06593; CAA29815.1; -; mRNA.
DR PIR; S01063; S01063.
DR PIR; S01064; S01064.
DR AlphaFoldDB; P04476; -.
DR SMR; P04476; -.
DR OMA; HPNLPMV; -.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..220
FT /note="Homeobox protein Hox-B7-B"
FT /id="PRO_0000200147"
FT DNA_BIND 138..197
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 195..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 127..132
FT /note="Antp-type hexapeptide"
FT VAR_SEQ 135..146
FT /note="GSDRKRGRQTYT -> DPVMMKVSSKPL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_002390"
FT VAR_SEQ 147..220
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_002391"
SQ SEQUENCE 220 AA; 25115 MW; 0C8E63B70BAC9E82 CRC64;
MSSLYYANAL FSKYPTATSV FPSGVFSEQT SCAFASSPQR SGYGNSPGGT FPAGSAAHGL
FSNGSSLHPQ SPAMYPSSYG LDAASFNMHC SPFEQNLSSL MCDPTKQNCT KAEQRDSELH
NEANLRIYPW MRSAGSDRKR GRQTYTRYQT LELEKEFHFN RYLTRRRRIE IAHTLCLTER
QIKIWFQNRR MKWKKENKAS SPSSNSQEKP ETEEEEEEEE
