ID   HXB7_BOVIN              Reviewed;         217 AA.
AC   Q9TT89;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Homeobox protein Hox-B7;
GN   Name=HOXB7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10842316;
RX   DOI=10.1002/(sici)1097-4644(20000801)78:2<210::aid-jcb4>3.0.co;2-z;
RA   Bostrom K., Tintut Y., Kao S.C., Stanford W.P., Demer L.L.;
RT   "HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth
RT   muscle cells.";
RL   J. Cell. Biochem. 78:210-221(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000250|UniProtKB:P09629}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF200721; AAF17552.1; -; mRNA.
DR   RefSeq; NP_776767.1; NM_174342.2.
DR   AlphaFoldDB; Q9TT89; -.
DR   SMR; Q9TT89; -.
DR   STRING; 9913.ENSBTAP00000007292; -.
DR   PaxDb; Q9TT89; -.
DR   GeneID; 281820; -.
DR   KEGG; bta:281820; -.
DR   CTD; 3217; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; Q9TT89; -.
DR   OrthoDB; 1203627at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..217
FT                   /note="Homeobox protein Hox-B7"
FT                   /id="PRO_0000200141"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          193..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           126..131
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   217 AA;  23941 MW;  4E0EB4C534F08884 CRC64;
     MSSLYYANAL FSKYPAASSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP
     GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA
     ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHALCLTERQ
     IKIWFQNRRM KWKKENKTSG PGTTGQDRAE AEEDEEE