HXB7_MOUSE
ID HXB7_MOUSE Reviewed; 217 AA.
AC P09024; A2A9Z9; Q3UW15;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Homeobox protein Hox-B7;
DE AltName: Full=Homeobox protein Hox-2.3;
DE AltName: Full=Homeobox protein MH-22B;
DE AltName: Full=Homeobox protein MuB1;
GN Name=Hoxb7; Synonyms=Hox-2.3, Hoxb-7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2889183; DOI=10.1093/nar/15.17.6773;
RA Meijlink F., de Laaf R., Verrijzer P., Destree O., Kroezen V., Hilkens J.,
RA Deschamps J.;
RT "A mouse homeobox containing gene on chromosome 11: sequence and tissue-
RT specific expression.";
RL Nucleic Acids Res. 15:6773-6786(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2896332; DOI=10.1093/nar/16.6.2729;
RA Verrijzer P., de Graaff W., Deschamps J., Meijlink F.;
RT "Nucleotide sequence of the Hox2.3 gene region.";
RL Nucleic Acids Res. 16:2729-2729(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-217.
RX PubMed=2890503; DOI=10.1089/dna.1987.6.409;
RA Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.;
RT "New murine homeoboxes: structure, chromosomal assignment, and differential
RT expression in adult erythropoiesis.";
RL DNA 6:409-418(1987).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-217.
RX PubMed=2891608; DOI=10.1016/0888-7543(87)90011-5;
RA Hart C.P., Fainsod A., Ruddle F.H.;
RT "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes:
RT evolutionary and structural comparisons.";
RL Genomics 1:182-195(1987).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 137-196.
RX PubMed=2901346; DOI=10.1002/j.1460-2075.1988.tb03052.x;
RA Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
RT "Expression of multiple homeobox genes within diverse mammalian
RT haemopoietic lineages.";
RL EMBO J. 7:2131-2138(1988).
RN [8]
RP INTERACTION WITH PBX1.
RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT products of multiple murine Hox genes, some of which are themselves
RT oncogenes.";
RL Mol. Cell. Biol. 15:3786-3795(1995).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC PBX1. {ECO:0000269|PubMed:7791786}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; Y00436; CAA68494.1; -; Genomic_DNA.
DR EMBL; X06762; CAA29934.1; -; mRNA.
DR EMBL; AK136706; BAE23104.1; -; mRNA.
DR EMBL; AL645478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M18167; AAA37845.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M18400; AAA88245.1; -; Genomic_DNA.
DR EMBL; X14570; CAA32708.1; -; mRNA.
DR CCDS; CCDS25294.1; -.
DR PIR; A26846; WJMSX2.
DR RefSeq; NP_034590.2; NM_010460.2.
DR AlphaFoldDB; P09024; -.
DR SMR; P09024; -.
DR BioGRID; 200381; 1.
DR IntAct; P09024; 1.
DR STRING; 10090.ENSMUSP00000040121; -.
DR iPTMnet; P09024; -.
DR PhosphoSitePlus; P09024; -.
DR MaxQB; P09024; -.
DR PaxDb; P09024; -.
DR PRIDE; P09024; -.
DR ProteomicsDB; 273230; -.
DR Antibodypedia; 68878; 365 antibodies from 32 providers.
DR DNASU; 15415; -.
DR Ensembl; ENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721.
DR GeneID; 15415; -.
DR KEGG; mmu:15415; -.
DR UCSC; uc007lbr.1; mouse.
DR CTD; 3217; -.
DR MGI; MGI:96188; Hoxb7.
DR VEuPathDB; HostDB:ENSMUSG00000038721; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161230; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P09024; -.
DR OMA; LSMMCPG; -.
DR OrthoDB; 1203627at2759; -.
DR PhylomeDB; P09024; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15415; 1 hit in 74 CRISPR screens.
DR PRO; PR:P09024; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09024; protein.
DR Bgee; ENSMUSG00000038721; Expressed in embryonic post-anal tail and 84 other tissues.
DR Genevisible; P09024; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0030099; P:myeloid cell differentiation; IMP:MGI.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..217
FT /note="Homeobox protein Hox-B7"
FT /id="PRO_0000200143"
FT DNA_BIND 137..196
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 192..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 126..131
FT /note="Antp-type hexapeptide"
FT CONFLICT 104
FT /note="P -> A (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="A -> G (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="Y -> S (in Ref. 3; BAE23104)"
FT /evidence="ECO:0000305"
FT CONFLICT 206
FT /note="Q -> H (in Ref. 5; AAA37845)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="A -> G (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="A -> R (in Ref. 6; AAA88245)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 23967 MW; 074AEB9D57EE88D7 CRC64;
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS
GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA
ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ
IKIWFQNRRM KWKKENKTSG PGTTGQDKAE AEEEEEE
