ID   HXB7_RAT                Reviewed;         219 AA.
AC   P18864; Q68FU9;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 172.
DE   RecName: Full=Homeobox protein Hox-B7;
DE   AltName: Full=Homeobox protein R1B;
GN   Name=Hoxb7; Synonyms=Hoxb-7, R1b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-199.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=2907739; DOI=10.1242/dev.103.3.601;
RA   Falzon M., Chung S.Y.;
RT   "The expression of rat homeobox-containing genes is developmentally
RT   regulated and tissue specific.";
RL   Development 103:601-610(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000250|UniProtKB:P09629}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Predominantly spinal cord and kidney.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA41342.2; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAA41342.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR   EMBL; BC079340; AAH79340.1; -; mRNA.
DR   EMBL; M37566; AAA41342.2; ALT_SEQ; Genomic_DNA.
DR   PIR; T10775; T10775.
DR   RefSeq; NP_001017480.1; NM_001017480.1.
DR   AlphaFoldDB; P18864; -.
DR   SMR; P18864; -.
DR   STRING; 10116.ENSRNOP00000033609; -.
DR   PhosphoSitePlus; P18864; -.
DR   PaxDb; P18864; -.
DR   Ensembl; ENSRNOT00000031035; ENSRNOP00000033609; ENSRNOG00000007611.
DR   GeneID; 497985; -.
DR   KEGG; rno:497985; -.
DR   UCSC; RGD:1559918; rat.
DR   CTD; 3217; -.
DR   RGD; 1559918; Hoxb7.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161230; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P18864; -.
DR   OMA; LSMMCPG; -.
DR   OrthoDB; 1203627at2759; -.
DR   PhylomeDB; P18864; -.
DR   TreeFam; TF316310; -.
DR   PRO; PR:P18864; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000007611; Expressed in kidney and 14 other tissues.
DR   Genevisible; P18864; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0048568; P:embryonic organ development; ISO:RGD.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR   GO; GO:0030099; P:myeloid cell differentiation; ISO:RGD.
DR   GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..219
FT                   /note="Homeobox protein Hox-B7"
FT                   /id="PRO_0000200144"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          193..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           126..131
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        173..174
FT                   /note="AL -> GV (in Ref. 2; AAA41342)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   219 AA;  24243 MW;  4917EA7ACC635DF9 CRC64;
     MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS
     GGGGMAGQSA AGVYEAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA
     ESNFRIYPWM RSSGTERKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHALCLTERQ
     IKIWFQNRRM KWKKENKTSG PGTTGQDKAE ADEEEEEEE