ID   HXB8_CHICK              Reviewed;          74 AA.
AC   P23681;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Homeobox protein Hox-B8;
DE   AltName: Full=Homeobox protein Hox-2.4;
DE            Short=Chox-2.4;
DE   Flags: Fragment;
GN   Name=HOXB8; Synonyms=CHOX-2.4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Comet Hubbard hybrid;
RX   PubMed=1973835; DOI=10.1093/nar/18.13.3999;
RA   Scotting P.J., Hewitt M., Keynes R.J.;
RT   "Isolation and analysis of chick homeobox cDNA clones.";
RL   Nucleic Acids Res. 18:3999-3999(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X52748; CAB57799.1; -; mRNA.
DR   PIR; S10884; S10884.
DR   AlphaFoldDB; P23681; -.
DR   SMR; P23681; -.
DR   PaxDb; P23681; -.
DR   VEuPathDB; HostDB:geneid_395711; -.
DR   InParanoid; P23681; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>74
FT                   /note="Homeobox protein Hox-B8"
FT                   /id="PRO_0000200152"
FT   DNA_BIND        39..>74
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           27..32
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         74
SQ   SEQUENCE   74 AA;  8642 MW;  406FCBE9BABD3EE1 CRC64;
     YTDCKLAASG LGEEAESSEQ SPSPTQLFPW MRPQAAAGRR RGRQTYSRYQ TLELEKEFLF
     NPYLTRKRRI EVSR