HXB8_MOUSE
ID HXB8_MOUSE Reviewed; 243 AA.
AC P09632;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 2.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Homeobox protein Hox-B8;
DE AltName: Full=Homeobox protein Hox-2.4;
GN Name=Hoxb8; Synonyms=Hox-2.4, Hoxb-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=2564662; DOI=10.1093/nar/17.5.1881;
RA Kongsuan K., Allen J., Adams J.M.;
RT "Expression of Hox-2.4 homeobox gene directed by proviral insertion in a
RT myeloid leukemia.";
RL Nucleic Acids Res. 17:1881-1892(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=2907477; DOI=10.1002/j.1460-2075.1988.tb03326.x;
RA Blatt C., Aberdam D., Schwartz R., Sachs L.;
RT "DNA rearrangement of a homeobox gene in myeloid leukaemic cells.";
RL EMBO J. 7:4283-4290(1988).
RN [3]
RP SEQUENCE REVISION.
RA Blatt C.;
RL Submitted (JUL-1989) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1673811; DOI=10.1016/0042-6822(91)90686-6;
RA Ben-David L., Aberdam D., Sachs L., Blatt C.;
RT "A deletion and a rearrangement distinguish between the intracisternal
RT A- particle of Hox-2.4 and that of interleukin-3 in the same leukemic
RT cells.";
RL Virology 182:382-387(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 144-243.
RX PubMed=2891608; DOI=10.1016/0888-7543(87)90011-5;
RA Hart C.P., Fainsod A., Ruddle F.H.;
RT "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes:
RT evolutionary and structural comparisons.";
RL Genomics 1:182-195(1987).
RN [6]
RP INTERACTION WITH PBX1.
RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT products of multiple murine Hox genes, some of which are themselves
RT oncogenes.";
RL Mol. Cell. Biol. 15:3786-3795(1995).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC PBX1. {ECO:0000269|PubMed:7791786}.
CC -!- INTERACTION:
CC P09632; P41778: Pbx1; NbExp=4; IntAct=EBI-925374, EBI-6996259;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X13961; CAA32141.1; -; Genomic_DNA.
DR EMBL; X13721; CAA32000.1; -; mRNA.
DR EMBL; M18399; AAA88246.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X54077; CAA38014.1; -; Genomic_DNA.
DR CCDS; CCDS25293.1; -.
DR PIR; S03712; WJMS24.
DR RefSeq; NP_034591.1; NM_010461.2.
DR RefSeq; XP_017169784.1; XM_017314295.1.
DR RefSeq; XP_017169785.1; XM_017314296.1.
DR RefSeq; XP_017169786.1; XM_017314297.1.
DR AlphaFoldDB; P09632; -.
DR SMR; P09632; -.
DR BioGRID; 200382; 14.
DR DIP; DIP-35618N; -.
DR IntAct; P09632; 15.
DR STRING; 10090.ENSMUSP00000052496; -.
DR iPTMnet; P09632; -.
DR PhosphoSitePlus; P09632; -.
DR MaxQB; P09632; -.
DR PaxDb; P09632; -.
DR PRIDE; P09632; -.
DR ProteomicsDB; 273231; -.
DR Antibodypedia; 30298; 215 antibodies from 27 providers.
DR DNASU; 15416; -.
DR Ensembl; ENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
DR Ensembl; ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
DR GeneID; 15416; -.
DR KEGG; mmu:15416; -.
DR UCSC; uc007lbp.1; mouse.
DR CTD; 3218; -.
DR MGI; MGI:96189; Hoxb8.
DR VEuPathDB; HostDB:ENSMUSG00000056648; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161529; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; P09632; -.
DR OMA; SEDCCEK; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P09632; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15416; 1 hit in 76 CRISPR screens.
DR PRO; PR:P09632; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09632; protein.
DR Bgee; ENSMUSG00000056648; Expressed in lumbar subsegment of spinal cord and 107 other tissues.
DR ExpressionAtlas; P09632; baseline and differential.
DR Genevisible; P09632; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0021516; P:dorsal spinal cord development; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0007625; P:grooming behavior; IMP:MGI.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..243
FT /note="Homeobox protein Hox-B8"
FT /id="PRO_0000200149"
FT DNA_BIND 146..205
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 203..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 134..139
FT /note="Antp-type hexapeptide"
SQ SEQUENCE 243 AA; 27618 MW; 368964C77884D21F CRC64;
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG
PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS
HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG
DKK
