HXB9_HUMAN
ID HXB9_HUMAN Reviewed; 250 AA.
AC P17482; B2RDB7; Q9H1I1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 200.
DE RecName: Full=Homeobox protein Hox-B9;
DE AltName: Full=Homeobox protein Hox-2.5;
DE AltName: Full=Homeobox protein Hox-2E;
GN Name=HOXB9; Synonyms=HOX2E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11857506; DOI=10.1002/tera.10009;
RA Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA Tomita M., McGinnis W., Matsuo N.;
RT "Complete mutation analysis panel of the 39 human HOX genes.";
RL Teratology 65:50-62(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-250.
RC TISSUE=Placenta;
RX PubMed=2570724; DOI=10.1111/j.1432-0436.1989.tb00598.x;
RA Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M.,
RA Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E.,
RA Peschle C.;
RT "Differential expression of human HOX-2 genes along the anterior-posterior
RT axis in embryonic central nervous system.";
RL Differentiation 40:191-197(1989).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-250.
RX PubMed=2576652; DOI=10.1139/g89-133;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-133, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-117, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P17482; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-745290, EBI-953896;
CC P17482; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-745290, EBI-739580;
CC P17482; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-745290, EBI-3866279;
CC P17482; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-745290, EBI-3867333;
CC P17482; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-745290, EBI-371922;
CC P17482; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-745290, EBI-12193763;
CC P17482; Q5TD97: FHL5; NbExp=3; IntAct=EBI-745290, EBI-750641;
CC P17482; Q08379: GOLGA2; NbExp=3; IntAct=EBI-745290, EBI-618309;
CC P17482; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-745290, EBI-5916454;
CC P17482; P49639: HOXA1; NbExp=3; IntAct=EBI-745290, EBI-740785;
CC P17482; Q16082: HSPB2; NbExp=3; IntAct=EBI-745290, EBI-739395;
CC P17482; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-745290, EBI-3044087;
CC P17482; O76011: KRT34; NbExp=3; IntAct=EBI-745290, EBI-1047093;
CC P17482; Q6A162: KRT40; NbExp=3; IntAct=EBI-745290, EBI-10171697;
CC P17482; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-745290, EBI-11959885;
CC P17482; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-745290, EBI-11749135;
CC P17482; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-745290, EBI-11741292;
CC P17482; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-745290, EBI-10171774;
CC P17482; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-745290, EBI-10172052;
CC P17482; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-745290, EBI-10176379;
CC P17482; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-745290, EBI-11988175;
CC P17482; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-745290, EBI-1048945;
CC P17482; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-745290, EBI-14065470;
CC P17482; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-745290, EBI-9996449;
CC P17482; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-745290, EBI-751260;
CC P17482; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-745290, EBI-10172511;
CC P17482; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-745290, EBI-11987425;
CC P17482; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-745290, EBI-3958099;
CC P17482; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-745290, EBI-11962084;
CC P17482; Q9BRK4: LZTS2; NbExp=4; IntAct=EBI-745290, EBI-741037;
CC P17482; Q99750: MDFI; NbExp=6; IntAct=EBI-745290, EBI-724076;
CC P17482; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-745290, EBI-10172526;
CC P17482; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-745290, EBI-11522433;
CC P17482; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-745290, EBI-22310682;
CC P17482; O43482: OIP5; NbExp=3; IntAct=EBI-745290, EBI-536879;
CC P17482; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-745290, EBI-11956269;
CC P17482; Q99471: PFDN5; NbExp=3; IntAct=EBI-745290, EBI-357275;
CC P17482; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-745290, EBI-949255;
CC P17482; Q8ND90: PNMA1; NbExp=6; IntAct=EBI-745290, EBI-302345;
CC P17482; O15160: POLR1C; NbExp=3; IntAct=EBI-745290, EBI-1055079;
CC P17482; P21673: SAT1; NbExp=6; IntAct=EBI-745290, EBI-711613;
CC P17482; Q9UHJ3: SFMBT1; NbExp=3; IntAct=EBI-745290, EBI-747398;
CC P17482; Q6N022: TENM4; NbExp=3; IntAct=EBI-745290, EBI-12827077;
CC P17482; Q63HR2: TNS2; NbExp=3; IntAct=EBI-745290, EBI-949753;
CC P17482; P14373: TRIM27; NbExp=3; IntAct=EBI-745290, EBI-719493;
CC P17482; Q15654: TRIP6; NbExp=3; IntAct=EBI-745290, EBI-742327;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9
CC weeks from conception.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY014296; AAG42144.1; -; Genomic_DNA.
DR EMBL; AY014295; AAG42144.1; JOINED; Genomic_DNA.
DR EMBL; AK315480; BAG37864.1; -; mRNA.
DR EMBL; CH471109; EAW94721.1; -; Genomic_DNA.
DR EMBL; BC015565; AAH15565.1; -; mRNA.
DR EMBL; X16172; CAA34294.1; -; Genomic_DNA.
DR CCDS; CCDS11534.1; -.
DR PIR; A37042; A37042.
DR RefSeq; NP_076922.1; NM_024017.4.
DR AlphaFoldDB; P17482; -.
DR SMR; P17482; -.
DR BioGRID; 109459; 115.
DR IntAct; P17482; 88.
DR MINT; P17482; -.
DR STRING; 9606.ENSP00000309439; -.
DR iPTMnet; P17482; -.
DR PhosphoSitePlus; P17482; -.
DR BioMuta; HOXB9; -.
DR DMDM; 20141507; -.
DR jPOST; P17482; -.
DR MassIVE; P17482; -.
DR PaxDb; P17482; -.
DR PeptideAtlas; P17482; -.
DR PRIDE; P17482; -.
DR ProteomicsDB; 53476; -.
DR Antibodypedia; 17861; 320 antibodies from 33 providers.
DR DNASU; 3219; -.
DR Ensembl; ENST00000311177.7; ENSP00000309439.5; ENSG00000170689.10.
DR GeneID; 3219; -.
DR KEGG; hsa:3219; -.
DR MANE-Select; ENST00000311177.7; ENSP00000309439.5; NM_024017.5; NP_076922.1.
DR UCSC; uc002inx.4; human.
DR CTD; 3219; -.
DR DisGeNET; 3219; -.
DR GeneCards; HOXB9; -.
DR HGNC; HGNC:5120; HOXB9.
DR HPA; ENSG00000170689; Tissue enhanced (epididymis, intestine).
DR MIM; 142964; gene.
DR neXtProt; NX_P17482; -.
DR OpenTargets; ENSG00000170689; -.
DR PharmGKB; PA29396; -.
DR VEuPathDB; HostDB:ENSG00000170689; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161386; -.
DR HOGENOM; CLU_071854_1_0_1; -.
DR InParanoid; P17482; -.
DR OMA; EDSKDIC; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P17482; -.
DR TreeFam; TF317819; -.
DR PathwayCommons; P17482; -.
DR SignaLink; P17482; -.
DR SIGNOR; P17482; -.
DR BioGRID-ORCS; 3219; 27 hits in 1104 CRISPR screens.
DR ChiTaRS; HOXB9; human.
DR GeneWiki; HOXB9; -.
DR GenomeRNAi; 3219; -.
DR Pharos; P17482; Tbio.
DR PRO; PR:P17482; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P17482; protein.
DR Bgee; ENSG00000170689; Expressed in mucosa of transverse colon and 74 other tissues.
DR Genevisible; P17482; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..250
FT /note="Homeobox protein Hox-B9"
FT /id="PRO_0000200155"
FT DNA_BIND 185..244
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 21..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 133
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 117
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CONFLICT 173
FT /note="T -> A (in Ref. 5; CAA34294)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 28059 MW; F06ECBC08FBBED2C CRC64;
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM
KKMNKEQGKE
