HXB9_MOUSE
ID HXB9_MOUSE Reviewed; 250 AA.
AC P20615; A2A9Z6;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Homeobox protein Hox-B9;
DE AltName: Full=Homeobox protein Hox-2.5;
GN Name=Hoxb9; Synonyms=Hox-2.5, Hoxb-9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8105876; DOI=10.1016/0925-4773(93)90003-g;
RA Malicki J., Bogarad L.D., Martin M.M., Ruddle F.H., McGinnis W.;
RT "Functional analysis of the mouse homeobox gene HoxB9 in Drosophila
RT development.";
RL Mech. Dev. 42:139-150(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
RX PubMed=1360646; DOI=10.1093/nar/20.21.5729;
RA Kondo T., Takahashi N., Muramatsu M.;
RT "The regulation of the murine Hox-2.5 gene expression during cell
RT differentiation.";
RL Nucleic Acids Res. 20:5729-5735(1992).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 124-250.
RX PubMed=2567250; DOI=10.1016/0012-1606(89)90056-0;
RA Bogarad L.D., Utset M.F., Awgulewitsch A., Miki T., Hart C.P., Ruddle F.H.;
RT "The developmental expression pattern of a new murine homeo box gene: Hox-
RT 2.5.";
RL Dev. Biol. 133:537-549(1989).
RN [6]
RP NUCLEOTIDE SEQUENCE OF 185-244.
RX PubMed=2566383; DOI=10.1016/0092-8674(89)90912-4;
RA Graham A., Papalopulu N., Krumlauf R.;
RT "The murine and Drosophila homeobox gene complexes have common features of
RT organization and expression.";
RL Cell 57:367-378(1989).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; S66855; AAB28828.1; -; mRNA.
DR EMBL; AL645478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466556; EDL16022.1; -; Genomic_DNA.
DR EMBL; X64316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M34857; AAA37847.1; -; mRNA.
DR CCDS; CCDS25292.1; -.
DR PIR; A56572; A56572.
DR RefSeq; NP_032296.2; NM_008270.2.
DR AlphaFoldDB; P20615; -.
DR SMR; P20615; -.
DR BioGRID; 200383; 1.
DR STRING; 10090.ENSMUSP00000000010; -.
DR PhosphoSitePlus; P20615; -.
DR MaxQB; P20615; -.
DR PaxDb; P20615; -.
DR PeptideAtlas; P20615; -.
DR PRIDE; P20615; -.
DR ProteomicsDB; 266930; -.
DR Antibodypedia; 17861; 320 antibodies from 33 providers.
DR DNASU; 15417; -.
DR Ensembl; ENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
DR GeneID; 15417; -.
DR KEGG; mmu:15417; -.
DR UCSC; uc007lbn.1; mouse.
DR CTD; 3219; -.
DR MGI; MGI:96190; Hoxb9.
DR VEuPathDB; HostDB:ENSMUSG00000020875; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161386; -.
DR HOGENOM; CLU_071854_1_0_1; -.
DR InParanoid; P20615; -.
DR OMA; EDSKDIC; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P20615; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 15417; 1 hit in 73 CRISPR screens.
DR PRO; PR:P20615; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P20615; protein.
DR Bgee; ENSMUSG00000020875; Expressed in embryonic post-anal tail and 98 other tissues.
DR ExpressionAtlas; P20615; baseline and differential.
DR Genevisible; P20615; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..250
FT /note="Homeobox protein Hox-B9"
FT /id="PRO_0000200156"
FT DNA_BIND 185..244
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 21..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 133
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P17482"
FT CROSSLNK 117
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P17482"
FT CONFLICT 62
FT /note="S -> T (in Ref. 1; AAB28828)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="D -> G (in Ref. 1; AAB28828 and 5; AAA37847)"
FT /evidence="ECO:0000305"
FT CONFLICT 245..247
FT /note="KEQ -> NGA (in Ref. 5; AAA37847)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 28015 MW; 2E14D2F9C34D1CE3 CRC64;
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC SFQPKAPVFG
ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE PAPRAEAAPG QGQAAVKAEP
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRAGYGDNKI CEGSEDKERP DQTNPSANWL
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM
KKMNKEQGKE
