ID   HXB9_XENLA              Reviewed;         232 AA.
AC   P31272;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Homeobox protein Hox-B9;
DE   AltName: Full=XlHbox-6;
GN   Name=hoxb9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=1976504; DOI=10.1242/dev.109.1.225;
RA   Wright C.V.E., Morita E.A., Wilkin D.J., De Robertis E.M.;
RT   "The Xenopus XIHbox 6 homeo protein, a marker of posterior neural
RT   induction, is expressed in proliferating neurons.";
RL   Development 109:225-234(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-186, AND FUNCTION.
RC   TISSUE=Gastrula;
RX   PubMed=2441873; DOI=10.1016/0092-8674(87)90333-3;
RA   Sharpe C.R., Fritz A., De Robertis E.M., Gurdon J.B.;
RT   "A homeobox-containing marker of posterior neural differentiation shows the
RT   importance of predetermination in neural induction.";
RL   Cell 50:749-758(1987).
RN   [3]
RP   INDUCTION.
RX   PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA   Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA   DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT   "derriere: a TGF-beta family member required for posterior development in
RT   Xenopus.";
RL   Development 126:1467-1482(1999).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC       {ECO:0000269|PubMed:2441873}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000269|PubMed:1976504}.
CC   -!- INDUCTION: By derriere. {ECO:0000269|PubMed:10068640}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; M17447; AAA69969.1; ALT_SEQ; mRNA.
DR   PIR; A60083; A60083.
DR   AlphaFoldDB; P31272; -.
DR   SMR; P31272; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR006711; Hox9_activation_N.
DR   InterPro; IPR017112; HXA9/HXB9/HXC9.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF04617; Hox9_act; 1.
DR   PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Homeobox protein Hox-B9"
FT                   /id="PRO_0000200158"
FT   DNA_BIND        167..226
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          22..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1..34
FT                   /note="MAISGPLTNYFVQSIISPDTDETPAAKFSAQFPN -> MGLDAHRVARLDLA
FT                   RIPLCAIPQ (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57
FT                   /note="F -> P (in Ref. 2; AAA69969)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="Missing (in Ref. 2; AAA69969)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108..119
FT                   /note="DKLGPQHYTVAS -> TNWDPNITLWP (in Ref. 2; AAA69969)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="E -> D (in Ref. 2; AAA69969)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   232 AA;  26238 MW;  F8DC4E6003098857 CRC64;
     MAISGPLTNY FVQSIISPDT DETPAAKFSA QFPNPRAPAQ SEPLDFPSCS FSASWNFLTP
     HPPVYQPYIQ QQQQQEEGAP SAEGRYLRAW LDNGPSLKSE PLLGPPGDKL GPQHYTVASP
     GGAAANTERS THSGNFPDTK GTEGTAGETD RTHQNNPSAN WLHARSSRKK RCPYSKYQTL
     ELEKEFKFNM YLTRDRRHEV ARLLNLSERQ VKIWFQNRRM KMKKLNKDQS KD