ID   HXBAA_DANRE             Reviewed;         279 AA.
AC   Q9PWL7; A9JTD5; B3DK18; O57361;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Homeobox protein Hox-B10a;
DE            Short=Hox-B10;
GN   Name=hoxb10a; Synonyms=hoxb10;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Singapore; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 190-279.
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 241-279, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: At the 10-somite stage, expressed in the paraxial
CC       mesoderm with an anterior expression limit at somite 9. At the 20-
CC       somite stage, expressed in the developing CNS with an anterior
CC       expression limit adjacent to the somite 7/somite 8 boundary.
CC       {ECO:0000269|PubMed:9425136}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD15943.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI55299.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC155298; AAI55299.1; ALT_INIT; mRNA.
DR   EMBL; BC163689; AAI63689.1; -; mRNA.
DR   EMBL; AF071250; AAD15943.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Y14531; CAA74866.1; -; mRNA.
DR   AlphaFoldDB; Q9PWL7; -.
DR   SMR; Q9PWL7; -.
DR   STRING; 7955.ENSDARP00000099793; -.
DR   PaxDb; Q9PWL7; -.
DR   ZFIN; ZDB-GENE-000328-2; hoxb10a.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; Q9PWL7; -.
DR   PhylomeDB; Q9PWL7; -.
DR   PRO; PR:Q9PWL7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="Homeobox protein Hox-B10a"
FT                   /id="PRO_0000200159"
FT   DNA_BIND        206..265
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          91..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        191
FT                   /note="V -> E (in Ref. 2; AAD15943)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   279 AA;  32001 MW;  222AA7837FB3E000 CRC64;
     MALHRHPFVH GAASWDGEQP SPVQLPHISA CPFTSSGRKE DPFYFTLDPT GQARQPLDIS
     AFSRIMTDMG SLNSADDHRP ETSFYSGHKL LSLNTDTDPE SPSLSSHSDS QHLHSLSLSA
     PCSETDNKHD MQYLAMESTK YPSQWSESRT NRSIITTLSI SQRSKDDIEP NNLQTDFTRG
     DKTPREKTQD VTLENAANGW LSAKAGRKKR CPYSKHQILE LEKEFLFNMY LTRERRLEIS
     RSINLTDRQV KIWFQNRRMK LKKMTREHRT RDPGTSFTV