HXBDA_DANRE
ID HXBDA_DANRE Reviewed; 303 AA.
AC Q1ECY2; Q4PR98;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Homeobox protein Hox-B13a;
GN Name=hoxb13a {ECO:0000312|EMBL:AAY67923.1,
GN ECO:0000312|ZFIN:ZDB-GENE-050812-1}; ORFNames=zgc:136601;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAI17626.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva {ECO:0000312|EMBL:AAI17626.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAY67923.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 135-233, AND DEVELOPMENTAL STAGE.
RC STRAIN=Tuebingen {ECO:0000269|PubMed:16174031};
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000250|UniProtKB:Q92826}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92826,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: At 24 hours post-fertilization, expression is
CC restricted to the tip of the developing tail.
CC {ECO:0000269|PubMed:16174031}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000255}.
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DR EMBL; BC117625; AAI17626.1; -; mRNA.
DR EMBL; DQ060545; AAY67923.1; -; mRNA.
DR RefSeq; NP_001038377.1; NM_001044912.1.
DR AlphaFoldDB; Q1ECY2; -.
DR SMR; Q1ECY2; -.
DR STRING; 7955.ENSDARP00000072890; -.
DR PaxDb; Q1ECY2; -.
DR Ensembl; ENSDART00000078428; ENSDARP00000072890; ENSDARG00000056015.
DR GeneID; 559921; -.
DR KEGG; dre:559921; -.
DR CTD; 559921; -.
DR ZFIN; ZDB-GENE-050812-1; hoxb13a.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000159029; -.
DR HOGENOM; CLU_059940_1_0_1; -.
DR InParanoid; Q1ECY2; -.
DR OMA; HPPDGCA; -.
DR OrthoDB; 1190384at2759; -.
DR PhylomeDB; Q1ECY2; -.
DR TreeFam; TF330813; -.
DR PRO; PR:Q1ECY2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000056015; Expressed in intestine and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..303
FT /note="Homeobox protein Hox-B13a"
FT /id="PRO_0000248262"
FT DNA_BIND 236..295
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 303 AA; 33773 MW; A6CCEC08A849C377 CRC64;
MTTSLVLNPR WADTVMFVYE NNLDELKNME GLVGSGNFAA NQCRNLMAHS ALSGHPSSLV
HGSSYPTVDV STSSSAESGK QCTPCPTVPQ ASSTGPIPYG YFGNSYYPCR MGRGSLKSCT
QPSALSYTAE KYMDTPVTSE EYPTRAKEFA FYHSYPSPYQ SMASYLDVSV VQTLGTGEPR
HDSLLPMDSY QPWALANGWG SQMYCSKDQG QAGHLWKSAL ADVVAHQHDG GSFRRGRKKR
IPYTKVQLKE LEKEYAANKF ITKDKRRKIS AVTNLSERQI TIWFQNRRVK EKKFIAKVKN
TAP