ID   HXBDA_TAKRU             Reviewed;         320 AA.
AC   Q1KKY3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Homeobox protein Hox-B13a;
GN   Name=hoxb13a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481665; ABF22411.1; -; Genomic_DNA.
DR   RefSeq; XP_003964304.1; XM_003964255.1.
DR   AlphaFoldDB; Q1KKY3; -.
DR   SMR; Q1KKY3; -.
DR   STRING; 31033.ENSTRUP00000013975; -.
DR   Ensembl; ENSTRUT00000058245; ENSTRUP00000052292; ENSTRUG00000023485.
DR   GeneID; 101072102; -.
DR   KEGG; tru:101072102; -.
DR   CTD; 559921; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000159029; -.
DR   InParanoid; Q1KKY3; -.
DR   OMA; AETSKQC; -.
DR   OrthoDB; 1190384at2759; -.
DR   TreeFam; TF330813; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..320
FT                   /note="Homeobox protein Hox-B13a"
FT                   /id="PRO_0000265985"
FT   DNA_BIND        253..312
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   320 AA;  34990 MW;  4264E293645F5370 CRC64;
     MTTSLVLNPR WPADTVMFVY ENNLDDLNKN MEGLVGSGNF AASQCRNIMA HSAAAAALGG
     HPSGLVHSST GYSTVDVTAT SSNDTLTSSG KQCATGPCPA ATVPHQSSSA ATALPYSYFG
     NGYYPCRMGR GSLKSCTQAA GAALSSQYMD TTVNSDEYSN HRAKEFAFYH SYPSPYQSMA
     SYLDVSVVQT LGAGEPRHDT LLPMDSYQPW ALTNGWGGQM YCSKDQGQAG HLWKSALADV
     VAHQHDGSPF RRGRKKRIPY TKVQLKELEK EYAANKFITK DKRRKISAAT NLSERQITIW
     FQNRRVKEKK FVAKVKSNAP