HXC10_MOUSE
ID HXC10_MOUSE Reviewed; 342 AA.
AC P31257; P31312; Q7TMT7;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Homeobox protein Hox-C10;
DE AltName: Full=Homeobox protein Hox-3.6;
GN Name=Hoxc10; Synonyms=Hox-3.6, Hoxc-10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CD-1;
RX PubMed=1353983; DOI=10.1016/0925-4773(92)90077-w;
RA Peterson R.L., Jacobs D.F., Awgulewitsch A.;
RT "Hox-3.6: isolation and characterization of a new murine homeobox gene
RT located in the 5' region of the Hox-3 cluster.";
RL Mech. Dev. 37:151-166(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Mesenchymal stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 268-327.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; X63507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053405; AAH53405.1; -; mRNA.
DR EMBL; M81658; AAA63310.1; -; Genomic_DNA.
DR CCDS; CCDS57014.1; -.
DR PIR; A56552; A56552.
DR RefSeq; NP_034592.2; NM_010462.5.
DR AlphaFoldDB; P31257; -.
DR SMR; P31257; -.
DR BioGRID; 229079; 1.
DR STRING; 10090.ENSMUSP00000001699; -.
DR PhosphoSitePlus; P31257; -.
DR jPOST; P31257; -.
DR MaxQB; P31257; -.
DR PaxDb; P31257; -.
DR PRIDE; P31257; -.
DR ProteomicsDB; 266931; -.
DR Antibodypedia; 15311; 444 antibodies from 34 providers.
DR DNASU; 209448; -.
DR Ensembl; ENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
DR GeneID; 209448; -.
DR KEGG; mmu:209448; -.
DR UCSC; uc007xwz.2; mouse.
DR CTD; 3226; -.
DR MGI; MGI:96192; Hoxc10.
DR VEuPathDB; HostDB:ENSMUSG00000022484; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000160855; -.
DR HOGENOM; CLU_057871_0_0_1; -.
DR InParanoid; P31257; -.
DR OMA; TPHCAGA; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31257; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 209448; 0 hits in 75 CRISPR screens.
DR PRO; PR:P31257; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P31257; protein.
DR Bgee; ENSMUSG00000022484; Expressed in embryonic post-anal tail and 99 other tissues.
DR Genevisible; P31257; MM.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..342
FT /note="Homeobox protein Hox-C10"
FT /id="PRO_0000200191"
FT DNA_BIND 268..327
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT CROSSLNK 106
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT CROSSLNK 195
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT CROSSLNK 254
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT CONFLICT 182
FT /note="P -> S (in Ref. 2; AAH53405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 38196 MW; 7BB2E117A768F52B CRC64;
MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG
SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL
NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
