HXC11_MOUSE
ID HXC11_MOUSE Reviewed; 304 AA.
AC P31313; B9EI74;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Homeobox protein Hox-C11;
DE AltName: Full=Homeobox protein Hox-3.7;
GN Name=Hoxc11; Synonyms=Hox-3.7, Hoxc-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 232-291.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AC160979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466550; EDL03950.1; -; Genomic_DNA.
DR EMBL; BC139233; AAI39234.1; -; mRNA.
DR EMBL; BC139269; AAI39270.1; -; mRNA.
DR CCDS; CCDS27892.1; -.
DR PIR; I37290; I37290.
DR RefSeq; NP_001020013.1; NM_001024842.1.
DR AlphaFoldDB; P31313; -.
DR SMR; P31313; -.
DR BioGRID; 224942; 1.
DR STRING; 10090.ENSMUSP00000001701; -.
DR PhosphoSitePlus; P31313; -.
DR PaxDb; P31313; -.
DR PRIDE; P31313; -.
DR ProteomicsDB; 266932; -.
DR Antibodypedia; 15309; 322 antibodies from 28 providers.
DR Ensembl; ENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656.
DR GeneID; 109663; -.
DR KEGG; mmu:109663; -.
DR UCSC; uc007xwy.1; mouse.
DR CTD; 3227; -.
DR MGI; MGI:96193; Hoxc11.
DR VEuPathDB; HostDB:ENSMUSG00000001656; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000160009; -.
DR HOGENOM; CLU_079662_0_0_1; -.
DR InParanoid; P31313; -.
DR OMA; AYCGADN; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31313; -.
DR TreeFam; TF350668; -.
DR BioGRID-ORCS; 109663; 2 hits in 74 CRISPR screens.
DR PRO; PR:P31313; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P31313; protein.
DR Bgee; ENSMUSG00000001656; Expressed in embryonic post-anal tail and 34 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IGI:MGI.
DR GO; GO:0001656; P:metanephros development; IGI:MGI.
DR GO; GO:0001759; P:organ induction; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..304
FT /note="Homeobox protein Hox-C11"
FT /id="PRO_0000200195"
FT DNA_BIND 232..291
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 167..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 82
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O43248"
FT CROSSLNK 116
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O43248"
FT CROSSLNK 178
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O43248"
SQ SEQUENCE 304 AA; 33708 MW; CD91F6D2212751F4 CRC64;
MFNSVNLGNF CSPSRKERGA DFGERGSCTS NLYLPSCTYY VPEFSTVSSF LPQAPSRQIS
YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM HRECLPPSTV TEILMKNEGS
YGGHHHPSAP HAAPAGFYSS VNKNSVLPQA FDRFFDNAYC GGGDAPAEPP CSGKGEAKGE
PEAPPASGLA SRAEAGAEAE AEEENTNPSS SGSSHSATKE PAKGAAPNAP RTRKKRCPYS
KFQIRELERE FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG
NPLL
