ID   HXC12_HUMAN             Reviewed;         282 AA.
AC   P31275; Q9BXJ6;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 177.
DE   RecName: Full=Homeobox protein Hox-C12;
DE   AltName: Full=Homeobox protein Hox-3F;
GN   Name=HOXC12; Synonyms=HOC3F, HOX3F;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11857506; DOI=10.1002/tera.10009;
RA   Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA   Tomita M., McGinnis W., Matsuo N.;
RT   "Complete mutation analysis panel of the 39 human HOX genes.";
RL   Teratology 65:50-62(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-279.
RX   PubMed=2574852; DOI=10.1093/nar/17.24.10385;
RA   Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
RA   Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
RT   "The human HOX gene family.";
RL   Nucleic Acids Res. 17:10385-10402(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF328962; AAK16717.1; -; Genomic_DNA.
DR   EMBL; AF328963; AAK16717.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS8866.1; -.
DR   PIR; S14933; S14933.
DR   RefSeq; NP_776272.1; NM_173860.2.
DR   AlphaFoldDB; P31275; -.
DR   SMR; P31275; -.
DR   BioGRID; 109468; 5.
DR   STRING; 9606.ENSP00000243103; -.
DR   iPTMnet; P31275; -.
DR   PhosphoSitePlus; P31275; -.
DR   BioMuta; HOXC12; -.
DR   DMDM; 20141538; -.
DR   MassIVE; P31275; -.
DR   PaxDb; P31275; -.
DR   PeptideAtlas; P31275; -.
DR   PRIDE; P31275; -.
DR   ProteomicsDB; 54775; -.
DR   Antibodypedia; 27304; 182 antibodies from 24 providers.
DR   DNASU; 3228; -.
DR   Ensembl; ENST00000243103.4; ENSP00000243103.3; ENSG00000123407.4.
DR   GeneID; 3228; -.
DR   KEGG; hsa:3228; -.
DR   MANE-Select; ENST00000243103.4; ENSP00000243103.3; NM_173860.3; NP_776272.1.
DR   UCSC; uc010soq.3; human.
DR   CTD; 3228; -.
DR   DisGeNET; 3228; -.
DR   GeneCards; HOXC12; -.
DR   HGNC; HGNC:5124; HOXC12.
DR   HPA; ENSG00000123407; Tissue enhanced (skin).
DR   MIM; 142975; gene.
DR   neXtProt; NX_P31275; -.
DR   OpenTargets; ENSG00000123407; -.
DR   PharmGKB; PA29399; -.
DR   VEuPathDB; HostDB:ENSG00000123407; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000161307; -.
DR   HOGENOM; CLU_087968_1_0_1; -.
DR   InParanoid; P31275; -.
DR   OMA; SYYREPC; -.
DR   OrthoDB; 1154178at2759; -.
DR   PhylomeDB; P31275; -.
DR   TreeFam; TF351604; -.
DR   PathwayCommons; P31275; -.
DR   BioGRID-ORCS; 3228; 13 hits in 1091 CRISPR screens.
DR   GeneWiki; HOXC12; -.
DR   GenomeRNAi; 3228; -.
DR   Pharos; P31275; Tbio.
DR   PRO; PR:P31275; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P31275; protein.
DR   Bgee; ENSG00000123407; Expressed in skin of leg and 16 other tissues.
DR   Genevisible; P31275; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Homeobox protein Hox-C12"
FT                   /id="PRO_0000200194"
FT   DNA_BIND        214..273
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          94..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   282 AA;  30171 MW;  493C53C511054A4D CRC64;
     MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP
     CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP
     GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK
     GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT
     RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF