ID   HXC12_MOUSE             Reviewed;         280 AA.
AC   Q8K5B8;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Homeobox protein Hox-C12;
DE   AltName: Full=Homeobox protein Hox-3.8;
GN   Name=Hoxc12; Synonyms=Hox-3.8, Hoxc-12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1;
RX   PubMed=11960714; DOI=10.1016/s0925-4773(02)00022-9;
RA   Shang L., Pruett N.D., Awgulewitsch A.;
RT   "Hoxc12 expression pattern in developing and cycling murine hair
RT   follicles.";
RL   Mech. Dev. 113:207-210(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF448482; AAM28679.1; -; mRNA.
DR   EMBL; BC120845; AAI20846.1; -; mRNA.
DR   EMBL; BC120847; AAI20848.1; -; mRNA.
DR   CCDS; CCDS27891.1; -.
DR   RefSeq; NP_034593.1; NM_010463.1.
DR   AlphaFoldDB; Q8K5B8; -.
DR   SMR; Q8K5B8; -.
DR   BioGRID; 200384; 8.
DR   IntAct; Q8K5B8; 8.
DR   STRING; 10090.ENSMUSP00000051003; -.
DR   iPTMnet; Q8K5B8; -.
DR   PhosphoSitePlus; Q8K5B8; -.
DR   MaxQB; Q8K5B8; -.
DR   PaxDb; Q8K5B8; -.
DR   PRIDE; Q8K5B8; -.
DR   Antibodypedia; 27304; 182 antibodies from 24 providers.
DR   DNASU; 15421; -.
DR   Ensembl; ENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
DR   GeneID; 15421; -.
DR   KEGG; mmu:15421; -.
DR   UCSC; uc007xww.1; mouse.
DR   CTD; 3228; -.
DR   MGI; MGI:96194; Hoxc12.
DR   VEuPathDB; HostDB:ENSMUSG00000050328; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000161307; -.
DR   HOGENOM; CLU_087968_1_0_1; -.
DR   InParanoid; Q8K5B8; -.
DR   OMA; SYYREPC; -.
DR   OrthoDB; 1154178at2759; -.
DR   PhylomeDB; Q8K5B8; -.
DR   TreeFam; TF351604; -.
DR   BioGRID-ORCS; 15421; 0 hits in 71 CRISPR screens.
DR   PRO; PR:Q8K5B8; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q8K5B8; protein.
DR   Bgee; ENSMUSG00000050328; Expressed in embryonic post-anal tail and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..280
FT                   /note="Homeobox protein Hox-C12"
FT                   /id="PRO_0000248840"
FT   DNA_BIND        212..271
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          95..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  30345 MW;  F42405EFC51AE60B CRC64;
     MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLPWPSAEP
     CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA EGGGGGLKRE ERGREPGAGP
     GAALLQLEPS GPPALGFKYD YTASGGGGDG STGPPHDPPS CQSLESDSSS SLLNEGNKSA
     SAGDPGSLVS PLNPGGGLSA SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ
     RRRELSDRLN LSDQQVKIWF QNRRMKKKRL LLREQALSFF