HXC13_MOUSE
ID HXC13_MOUSE Reviewed; 328 AA.
AC P50207; Q53Z78; Q920I7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Homeobox protein Hox-C13;
GN Name=Hoxc13; Synonyms=Hoxc-13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=FVB/NJ; TISSUE=Embryo;
RX PubMed=11290294; DOI=10.1242/dev.128.9.1547;
RA Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D.,
RA Ito T., Ogawa M., Awgulewitsch A.;
RT "Overexpression of Hoxc13 in differentiating keratinocytes results in
RT downregulation of a novel hair keratin gene cluster and alopecia.";
RL Development 128:1547-1558(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N;
RA Bruggeman L.A.;
RT "Hoxc13 expression in mouse kidney development and reactivated expression
RT during HIV-associated glomerulosclerosis.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-309.
RC STRAIN=C57BL/6J;
RX PubMed=7959778; DOI=10.1006/geno.1994.1371;
RA Bradshaw M.S., Ruddle F.H.;
RT "Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast
RT artificial chromosomes.";
RL Genomics 22:234-236(1994).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16835220; DOI=10.1074/jbc.m603646200;
RA Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F.,
RA Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.;
RT "Evidence that the satin hair mutant gene Foxq1 is among multiple and
RT functionally diverse regulatory targets for Hoxc13 during hair follicle
RT differentiation.";
RL J. Biol. Chem. 281:29245-29255(2006).
CC -!- FUNCTION: Transcription factor which plays a role in hair follicle
CC differentiation. Regulates FOXQ1 expression and that of other hair-
CC specific genes. {ECO:0000269|PubMed:11290294,
CC ECO:0000269|PubMed:16835220}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in differentiating keratinocytes. In the
CC hair follicle lower matrix, expressed in all 3 hair shaft-forming
CC compartments, i.e. cuticle, cortex and medulla. Expression stops
CC sharply at the boundary with the germinal matrix compartment.
CC {ECO:0000269|PubMed:11290294, ECO:0000269|PubMed:16835220}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AF193796; AAL09298.1; -; mRNA.
DR EMBL; AY349616; AAQ54690.1; -; mRNA.
DR EMBL; U04838; AAA20229.1; -; Genomic_DNA.
DR CCDS; CCDS27890.1; -.
DR PIR; I48924; I48924.
DR RefSeq; NP_034594.1; NM_010464.2.
DR AlphaFoldDB; P50207; -.
DR SMR; P50207; -.
DR BioGRID; 200385; 1.
DR IntAct; P50207; 1.
DR STRING; 10090.ENSMUSP00000001700; -.
DR PhosphoSitePlus; P50207; -.
DR PaxDb; P50207; -.
DR PRIDE; P50207; -.
DR ProteomicsDB; 266933; -.
DR Antibodypedia; 27302; 116 antibodies from 27 providers.
DR DNASU; 15422; -.
DR Ensembl; ENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
DR GeneID; 15422; -.
DR KEGG; mmu:15422; -.
DR UCSC; uc007xwv.1; mouse.
DR CTD; 3229; -.
DR MGI; MGI:99560; Hoxc13.
DR VEuPathDB; HostDB:ENSMUSG00000001655; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161087; -.
DR HOGENOM; CLU_059940_0_0_1; -.
DR InParanoid; P50207; -.
DR OMA; SKNNHMH; -.
DR OrthoDB; 1190384at2759; -.
DR PhylomeDB; P50207; -.
DR TreeFam; TF330813; -.
DR BioGRID-ORCS; 15422; 2 hits in 74 CRISPR screens.
DR PRO; PR:P50207; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P50207; protein.
DR Bgee; ENSMUSG00000001655; Expressed in lip and 30 other tissues.
DR Genevisible; P50207; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IMP:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR GO; GO:0035878; P:nail development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043587; P:tongue morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..328
FT /note="Homeobox protein Hox-C13"
FT /id="PRO_0000200198"
FT DNA_BIND 258..317
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 23..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 35193 MW; AE363563B5AEF776 CRC64;
MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG KAPSMDGLGG
SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA RQCAPPPAPP TSSSATLGYG
YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK YPEPSGALPG DDLSSRAKEF AFYPSFASSY
QAMPGYLDVS VVPGISGHPE PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS
PFPDVVPLQP EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER
QVTIWFQNRR VKEKKVVSKS KAPHLHST
