ID   HXC3A_DANRE             Reviewed;         250 AA.
AC   P28174;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Homeobox protein Hox-C3a;
DE   AltName: Full=Homeobox protein Zf-114;
DE   AltName: Full=Hox-114;
GN   Name=hoxc3a; Synonyms=zf114;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1356006;
RA   Molven A., Hordvik I., Njolstad P.R., van Ghelue M., Fjose A.;
RT   "The zebrafish homeobox gene hox[zf-114]: primary structure, expression
RT   pattern and evolutionary aspects.";
RL   Int. J. Dev. Biol. 36:229-237(1992).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X60095; CAA42691.1; -; mRNA.
DR   PIR; I50105; S15556.
DR   AlphaFoldDB; P28174; -.
DR   SMR; P28174; -.
DR   STRING; 7955.ENSDARP00000129398; -.
DR   PaxDb; P28174; -.
DR   ZFIN; ZDB-GENE-980526-532; hoxc3a.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P28174; -.
DR   PRO; PR:P28174; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..250
FT                   /note="Homeobox protein Hox-C3a"
FT                   /id="PRO_0000200163"
FT   DNA_BIND        145..204
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           107..112
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   250 AA;  29088 MW;  C40A37FBF35DD27E CRC64;
     MNNNSFHEYN FNSEYLNKIC CNKSYVCYMG QHFSPCALQE NSSTWKRHAE ESSSENDKGN
     VWNFQNLSNV QHPYSFSDDG NHSLDPANAL ERKKACELST SCLSTMKYPW MRETHAPTHF
     SSINAMESGD SKYSNGEAVV RNSSSKRARV AFTSSQLLEL EKEFHFSAYL CRNRRLEMAE
     LLKLTDRQIK IWFQNRRMKY KKDHKEKSTA KSSYTYLGTE NQPLIISRST TDSPVPLKFQ
     NNYETPSMNW