HXC4_HUMAN
ID HXC4_HUMAN Reviewed; 264 AA.
AC P09017;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 2.
DT 03-AUG-2022, entry version 202.
DE RecName: Full=Homeobox protein Hox-C4;
DE AltName: Full=Homeobox protein CP19;
DE AltName: Full=Homeobox protein Hox-3E;
GN Name=HOXC4; Synonyms=HOX3E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2898768; DOI=10.1093/nar/16.12.5379;
RA Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.;
RT "At least three human homeoboxes on chromosome 12 belong to the same
RT transcription unit.";
RL Nucleic Acids Res. 16:5379-5390(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11857506; DOI=10.1002/tera.10009;
RA Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA Tomita M., McGinnis W., Matsuo N.;
RT "Complete mutation analysis panel of the 39 human HOX genes.";
RL Teratology 65:50-62(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-221.
RX PubMed=2576652; DOI=10.1139/g89-133;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P09017; P01023: A2M; NbExp=3; IntAct=EBI-3923226, EBI-640741;
CC P09017; P54253: ATXN1; NbExp=6; IntAct=EBI-3923226, EBI-930964;
CC P09017; P49761: CLK3; NbExp=3; IntAct=EBI-3923226, EBI-745579;
CC P09017; P68400: CSNK2A1; NbExp=3; IntAct=EBI-3923226, EBI-347804;
CC P09017; G5E9A7: DMWD; NbExp=3; IntAct=EBI-3923226, EBI-10976677;
CC P09017; P50570-2: DNM2; NbExp=3; IntAct=EBI-3923226, EBI-10968534;
CC P09017; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-3923226, EBI-371876;
CC P09017; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-3923226, EBI-11110431;
CC P09017; P28799: GRN; NbExp=3; IntAct=EBI-3923226, EBI-747754;
CC P09017; Q5SUL5: HLA-A; NbExp=3; IntAct=EBI-3923226, EBI-8561769;
CC P09017; P42858: HTT; NbExp=16; IntAct=EBI-3923226, EBI-466029;
CC P09017; Q92993: KAT5; NbExp=3; IntAct=EBI-3923226, EBI-399080;
CC P09017; O60333-2: KIF1B; NbExp=3; IntAct=EBI-3923226, EBI-10975473;
CC P09017; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-3923226, EBI-11742507;
CC P09017; O43639: NCK2; NbExp=3; IntAct=EBI-3923226, EBI-713635;
CC P09017; Q9BZ95: NSD3; NbExp=2; IntAct=EBI-3923226, EBI-3390132;
CC P09017; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-3923226, EBI-473160;
CC P09017; P23284: PPIB; NbExp=3; IntAct=EBI-3923226, EBI-359252;
CC P09017; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-3923226, EBI-396669;
CC P09017; Q9NQG5: RPRD1B; NbExp=3; IntAct=EBI-3923226, EBI-747925;
CC P09017; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-3923226, EBI-9090795;
CC P09017; Q16637: SMN2; NbExp=3; IntAct=EBI-3923226, EBI-395421;
CC P09017; P37840: SNCA; NbExp=3; IntAct=EBI-3923226, EBI-985879;
CC P09017; P00441: SOD1; NbExp=3; IntAct=EBI-3923226, EBI-990792;
CC P09017; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-3923226, EBI-5235340;
CC P09017; O43463: SUV39H1; NbExp=2; IntAct=EBI-3923226, EBI-349968;
CC P09017; Q86WV8: TSC1; NbExp=3; IntAct=EBI-3923226, EBI-12806590;
CC P09017; P61981: YWHAG; NbExp=3; IntAct=EBI-3923226, EBI-359832;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
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DR EMBL; X07495; CAA30376.1; -; mRNA.
DR EMBL; AY014298; AAG42145.1; -; Genomic_DNA.
DR EMBL; AY014297; AAG42145.1; JOINED; Genomic_DNA.
DR EMBL; AC023794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS8873.1; -.
DR PIR; S01030; WJHU3E.
DR RefSeq; NP_055435.2; NM_014620.5.
DR RefSeq; NP_705897.1; NM_153633.2.
DR AlphaFoldDB; P09017; -.
DR SMR; P09017; -.
DR BioGRID; 109461; 32.
DR IntAct; P09017; 41.
DR MINT; P09017; -.
DR STRING; 9606.ENSP00000399808; -.
DR iPTMnet; P09017; -.
DR PhosphoSitePlus; P09017; -.
DR BioMuta; HOXC4; -.
DR DMDM; 281185468; -.
DR MassIVE; P09017; -.
DR MaxQB; P09017; -.
DR PaxDb; P09017; -.
DR PeptideAtlas; P09017; -.
DR PRIDE; P09017; -.
DR ProteomicsDB; 52186; -.
DR Antibodypedia; 27312; 301 antibodies from 27 providers.
DR DNASU; 3221; -.
DR Ensembl; ENST00000303406.4; ENSP00000305973.4; ENSG00000198353.8.
DR Ensembl; ENST00000430889.3; ENSP00000399808.2; ENSG00000198353.8.
DR GeneID; 3221; -.
DR KEGG; hsa:3221; -.
DR MANE-Select; ENST00000430889.3; ENSP00000399808.2; NM_153633.3; NP_705897.1.
DR UCSC; uc001seu.5; human.
DR CTD; 3221; -.
DR DisGeNET; 3221; -.
DR GeneCards; HOXC4; -.
DR HGNC; HGNC:5126; HOXC4.
DR HPA; ENSG00000198353; Tissue enhanced (fallopian).
DR MIM; 142974; gene.
DR neXtProt; NX_P09017; -.
DR OpenTargets; ENSG00000198353; -.
DR PharmGKB; PA29401; -.
DR VEuPathDB; HostDB:ENSG00000198353; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160794; -.
DR HOGENOM; CLU_061398_0_0_1; -.
DR InParanoid; P09017; -.
DR OMA; NGPDSKR; -.
DR OrthoDB; 1154159at2759; -.
DR PhylomeDB; P09017; -.
DR TreeFam; TF352857; -.
DR PathwayCommons; P09017; -.
DR Reactome; R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis.
DR SignaLink; P09017; -.
DR SIGNOR; P09017; -.
DR BioGRID-ORCS; 3221; 21 hits in 1078 CRISPR screens.
DR ChiTaRS; HOXC4; human.
DR GeneWiki; HOXC4; -.
DR GenomeRNAi; 3221; -.
DR Pharos; P09017; Tbio.
DR PRO; PR:P09017; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P09017; protein.
DR Bgee; ENSG00000198353; Expressed in right uterine tube and 174 other tissues.
DR ExpressionAtlas; P09017; baseline and differential.
DR Genevisible; P09017; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..264
FT /note="Homeobox protein Hox-C4"
FT /id="PRO_0000200164"
FT DNA_BIND 156..215
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 19..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 135..140
FT /note="Antp-type hexapeptide"
FT COMPBIAS 64..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 158
FT /note="R -> L (in dbSNP:rs11835301)"
FT /id="VAR_055961"
FT VARIANT 178
FT /note="N -> S (in dbSNP:rs35406888)"
FT /id="VAR_055962"
FT CONFLICT 161
FT /note="T -> A (in Ref. 1; CAA30376 and 2; AAG42145)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 29811 MW; 5CCD13995574226E CRC64;
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP
SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP APLSGASASP SPAPPACSQP
APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY
LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP
GTSEDHSQSA TPPEQQRAED ITRL
