HXC4_MOUSE
ID HXC4_MOUSE Reviewed; 264 AA.
AC Q08624;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Homeobox protein Hox-C4;
DE AltName: Full=Homeobox protein Hox-3.5;
GN Name=Hoxc4; Synonyms=Hox-3.5, Hoxc-4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=8099712; DOI=10.1007/bf00281599;
RA Goto J., Miyabayashi T., Wakamatsu Y., Takahashi N., Muramatsu M.-A.;
RT "Organization and expression of mouse Hox3 cluster genes.";
RL Mol. Gen. Genet. 239:41-48(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=1363091; DOI=10.1242/dev.116.2.497;
RA Geada A.M.C., Gaunt S.J., Azzawi M., Shimeld S.M., Pearce J., Sharpe P.T.;
RT "Sequence and embryonic expression of the murine Hox-3.5 gene.";
RL Development 116:497-506(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-201.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
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DR EMBL; D11328; BAA01947.1; -; Genomic_DNA.
DR EMBL; S62287; AAB27153.1; -; Genomic_DNA.
DR EMBL; X69019; CAA48784.1; -; mRNA.
DR EMBL; M81660; AAA63313.1; -; Genomic_DNA.
DR CCDS; CCDS27897.1; -.
DR PIR; S35219; S35219.
DR RefSeq; NP_038581.2; NM_013553.2.
DR RefSeq; XP_006520524.1; XM_006520461.2.
DR RefSeq; XP_006520525.1; XM_006520462.3.
DR RefSeq; XP_006520526.1; XM_006520463.2.
DR RefSeq; XP_011243762.1; XM_011245460.2.
DR AlphaFoldDB; Q08624; -.
DR SMR; Q08624; -.
DR BioGRID; 200386; 6.
DR IntAct; Q08624; 5.
DR STRING; 10090.ENSMUSP00000097740; -.
DR iPTMnet; Q08624; -.
DR PhosphoSitePlus; Q08624; -.
DR PaxDb; Q08624; -.
DR PRIDE; Q08624; -.
DR ProteomicsDB; 273232; -.
DR Antibodypedia; 27312; 301 antibodies from 27 providers.
DR DNASU; 15423; -.
DR Ensembl; ENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394.
DR GeneID; 15423; -.
DR KEGG; mmu:15423; -.
DR UCSC; uc007xxg.1; mouse.
DR CTD; 3221; -.
DR MGI; MGI:96195; Hoxc4.
DR VEuPathDB; HostDB:ENSMUSG00000075394; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160794; -.
DR HOGENOM; CLU_061398_0_0_1; -.
DR InParanoid; Q08624; -.
DR OMA; NGPDSKR; -.
DR OrthoDB; 1154159at2759; -.
DR PhylomeDB; Q08624; -.
DR TreeFam; TF352857; -.
DR BioGRID-ORCS; 15423; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q08624; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q08624; protein.
DR Bgee; ENSMUSG00000075394; Expressed in superior cervical ganglion and 100 other tissues.
DR ExpressionAtlas; Q08624; baseline and differential.
DR Genevisible; Q08624; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0071837; F:HMG box domain binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0051216; P:cartilage development; IMP:MGI.
DR GO; GO:0048562; P:embryonic organ morphogenesis; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:1904840; P:positive regulation of male germ-line stem cell asymmetric division; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..264
FT /note="Homeobox protein Hox-C4"
FT /id="PRO_0000200165"
FT DNA_BIND 156..215
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 19..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 135..140
FT /note="Antp-type hexapeptide"
FT COMPBIAS 64..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 80
FT /note="A -> G (in Ref. 2; CAA48784)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="P -> S (in Ref. 2; CAA48784)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 29865 MW; 35B0FA34B45BF30C CRC64;
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP
SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP APLSGTSASP SPAPPACSQP
APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY
LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP
GTSEDHSQSA TPPEQQRAED ITRL
