ID   HXC4_ORYLA              Reviewed;         261 AA.
AC   Q9PVS4;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Homeobox protein Hox-C4;
GN   Name=hoxc4; Synonyms=hoxc4a;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kondo S., Naruse K., Shima A.;
RT   "Hox genes of the medakafish Oryzias latipes.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB026955; BAA86238.1; -; mRNA.
DR   RefSeq; NP_001098348.1; NM_001104878.2.
DR   RefSeq; XP_011475037.1; XM_011476735.1.
DR   AlphaFoldDB; Q9PVS4; -.
DR   SMR; Q9PVS4; -.
DR   STRING; 8090.ENSORLP00000009978; -.
DR   Ensembl; ENSORLT00000009979; ENSORLP00000009978; ENSORLG00000007955.
DR   Ensembl; ENSORLT00015030554; ENSORLP00015021134; ENSORLG00015022346.
DR   Ensembl; ENSORLT00020005669; ENSORLP00020024944; ENSORLG00020006629.
DR   GeneID; 100125418; -.
DR   KEGG; ola:100125418; -.
DR   CTD; 30345; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000160794; -.
DR   HOGENOM; CLU_061398_0_0_1; -.
DR   InParanoid; Q9PVS4; -.
DR   OMA; NGPDSKR; -.
DR   OrthoDB; 1154159at2759; -.
DR   TreeFam; TF352857; -.
DR   Proteomes; UP000001038; Chromosome 7.
DR   Proteomes; UP000265180; Chromosome 7.
DR   Proteomes; UP000265200; Chromosome 7.
DR   Bgee; ENSORLG00000007955; Expressed in sexually immature organism and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..261
FT                   /note="Homeobox protein Hox-C4"
FT                   /id="PRO_0000200168"
FT   DNA_BIND        154..213
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          85..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           133..138
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        94..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..249
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29373 MW;  01890A19997E2B94 CRC64;
     MIMSSYLMES NYIDPKFPPC EEYSQNNYIP DSPEYYSRAR DTGYQHHHQE LYPPRASYQE
     RQYNCASIPE PDTPRGHGIP HSAHLLAGKG QPASCETPQL SMSPATPPAA ASACNQATPE
     HPNSTASSKQ PVVYPWMKKI HVSTVNSGYN GTEPKRSRTA YTRQQVLELE KEFHYNRYLT
     RRRRIEIAHT LVLSERQIKI WFQNRRMKWK KDHRLPNTKV RSSSSGSNTS SAAGGVAAAS
     ATNSGPDELS GAQHGEDITR L