ID   HXC5A_DANRE             Reviewed;         232 AA.
AC   P09074; O57368; Q4PR90;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Homeobox protein Hox-C5a;
DE            Short=Hox-C5;
DE   AltName: Full=Homeobox protein Hox-3.4;
DE   AltName: Full=Homeobox protein Zf-25;
GN   Name=hoxc5a; Synonyms=hox-3.4, hoxc5, zf25;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8104460;
RA   Ericson J.U., Krauss S., Fjose A.;
RT   "Genomic sequence and embryonic expression of the zebrafish homeobox gene
RT   hox-3.4.";
RL   Int. J. Dev. Biol. 37:263-272(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 74-174.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-232.
RX   PubMed=2892487; DOI=10.1016/0006-291x(87)90530-4;
RA   Eiken H.G., Njolstad P.R., Molven A., Fjose A.;
RT   "A zebrafish homeobox-containing gene with embryonic transcription.";
RL   Biochem. Biophys. Res. Commun. 149:1165-1171(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 194-232, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: At the 10-somite stage, barely expressed in the
CC       paraxial mesoderm. At the 20-somite stage, expressed in the developing
CC       CNS with an anterior expression limit at somite 1.
CC       {ECO:0000269|PubMed:9425136}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X68324; CAA48399.1; -; Genomic_DNA.
DR   EMBL; DQ060553; AAY67931.1; -; mRNA.
DR   EMBL; M18470; AAA50029.1; -; Genomic_DNA.
DR   EMBL; Y14539; CAA74874.1; -; mRNA.
DR   PIR; S48125; S48125.
DR   AlphaFoldDB; P09074; -.
DR   SMR; P09074; -.
DR   STRING; 7955.ENSDARP00000093908; -.
DR   ZFIN; ZDB-GENE-980526-533; hoxc5a.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P09074; -.
DR   PRO; PR:P09074; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Homeobox protein Hox-C5a"
FT                   /id="PRO_0000200171"
FT   DNA_BIND        165..224
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          112..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           150..155
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        120..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        122..133
FT                   /note="SRRYQNGDYFSD -> RTDDIKMETTSAI (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        230
FT                   /note="G -> A (in Ref. 4; CAA74874)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   232 AA;  26909 MW;  945BC0BB15CF3EE8 CRC64;
     MSSYVGKSFS KQTQDASSCR MHTFDNYGAH SEFHESNYAY EGLDLGGSFS SQIPTNSLRR
     EAINTTDRAR SSAAVQRTQS CSALGSRSFV STHGYNPLSH GLLSQKAEGN MEVMEKPSGK
     SSRRYQNGDY FSDKQQTNST QRQNQSQPQI YPWMTKLHMS HESDGKRSRT SYTRYQTLEL
     EKEFHFNRYL TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKLKVKG GL