ID   HXC5_HUMAN              Reviewed;         222 AA.
AC   Q00444;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 182.
DE   RecName: Full=Homeobox protein Hox-C5;
DE   AltName: Full=Homeobox protein CP11;
DE   AltName: Full=Homeobox protein Hox-3D;
GN   Name=HOXC5; Synonyms=HOX3D;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1346761; DOI=10.1002/j.1460-2075.1992.tb05049.x;
RA   Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E.,
RA   Mavilio F.;
RT   "The upstream region of the human homeobox gene HOX3D is a target for
RT   regulation by retinoic acid and HOX homeoproteins.";
RL   EMBO J. 11:265-277(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- INTERACTION:
CC       Q00444; P56545-3: CTBP2; NbExp=3; IntAct=EBI-11955357, EBI-10171902;
CC       Q00444; Q92997: DVL3; NbExp=3; IntAct=EBI-11955357, EBI-739789;
CC       Q00444; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-11955357, EBI-739467;
CC       Q00444; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11955357, EBI-12039345;
CC       Q00444; Q969G2: LHX4; NbExp=3; IntAct=EBI-11955357, EBI-2865388;
CC       Q00444; P40424: PBX1; NbExp=3; IntAct=EBI-11955357, EBI-301611;
CC       Q00444; P40425: PBX2; NbExp=3; IntAct=EBI-11955357, EBI-348489;
CC       Q00444; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-11955357, EBI-10302990;
CC       Q00444; P62487: POLR2G; NbExp=4; IntAct=EBI-11955357, EBI-347928;
CC       Q00444; P78424: POU6F2; NbExp=3; IntAct=EBI-11955357, EBI-12029004;
CC       Q00444; Q05516: ZBTB16; NbExp=3; IntAct=EBI-11955357, EBI-711925;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X61755; CAA43894.1; -; Genomic_DNA.
DR   CCDS; CCDS8872.1; -.
DR   PIR; S20029; S20029.
DR   RefSeq; NP_061826.1; NM_018953.3.
DR   AlphaFoldDB; Q00444; -.
DR   SMR; Q00444; -.
DR   BioGRID; 109462; 97.
DR   IntAct; Q00444; 11.
DR   STRING; 9606.ENSP00000309336; -.
DR   iPTMnet; Q00444; -.
DR   PhosphoSitePlus; Q00444; -.
DR   BioMuta; HOXC5; -.
DR   DMDM; 232262; -.
DR   jPOST; Q00444; -.
DR   MassIVE; Q00444; -.
DR   MaxQB; Q00444; -.
DR   PaxDb; Q00444; -.
DR   PeptideAtlas; Q00444; -.
DR   PRIDE; Q00444; -.
DR   ProteomicsDB; 57847; -.
DR   Antibodypedia; 27321; 129 antibodies from 19 providers.
DR   DNASU; 3222; -.
DR   Ensembl; ENST00000312492.3; ENSP00000309336.2; ENSG00000172789.4.
DR   GeneID; 3222; -.
DR   KEGG; hsa:3222; -.
DR   MANE-Select; ENST00000312492.3; ENSP00000309336.2; NM_018953.4; NP_061826.1.
DR   UCSC; uc001sew.4; human.
DR   CTD; 3222; -.
DR   DisGeNET; 3222; -.
DR   GeneCards; HOXC5; -.
DR   HGNC; HGNC:5127; HOXC5.
DR   HPA; ENSG00000172789; Tissue enhanced (brain, fallopian tube).
DR   MIM; 142973; gene.
DR   neXtProt; NX_Q00444; -.
DR   OpenTargets; ENSG00000172789; -.
DR   PharmGKB; PA29402; -.
DR   VEuPathDB; HostDB:ENSG00000172789; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161023; -.
DR   HOGENOM; CLU_061398_2_1_1; -.
DR   InParanoid; Q00444; -.
DR   OMA; DRPSCTV; -.
DR   PhylomeDB; Q00444; -.
DR   TreeFam; TF316310; -.
DR   BRENDA; 2.7.11.21; 2681.
DR   PathwayCommons; Q00444; -.
DR   SignaLink; Q00444; -.
DR   BioGRID-ORCS; 3222; 18 hits in 1091 CRISPR screens.
DR   GeneWiki; HOXC5; -.
DR   GenomeRNAi; 3222; -.
DR   Pharos; Q00444; Tbio.
DR   PRO; PR:Q00444; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q00444; protein.
DR   Bgee; ENSG00000172789; Expressed in left uterine tube and 59 other tissues.
DR   Genevisible; Q00444; HS.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..222
FT                   /note="Homeobox protein Hox-C5"
FT                   /id="PRO_0000200169"
FT   DNA_BIND        155..214
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          68..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           140..145
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   222 AA;  24976 MW;  9ABA38D35E4E61AB CRC64;
     MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG
     VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE
     EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL
     TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL