ID   HXC5_XENLA              Reviewed;          87 AA.
AC   P09020;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Homeobox protein Hox-C5;
DE   AltName: Full=XlHbox-5;
DE   Flags: Fragment;
GN   Name=hoxc5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2894634; DOI=10.1093/nar/16.4.1453;
RA   Fritz A., De Robertis E.M.;
RT   "Xenopus homeobox-containing cDNAs expressed in early development.";
RL   Nucleic Acids Res. 16:1453-1469(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed exclusively in early embryos.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X07105; CAA30126.1; -; mRNA.
DR   PIR; S00589; S00589.
DR   AlphaFoldDB; P09020; -.
DR   SMR; P09020; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..87
FT                   /note="Homeobox protein Hox-C5"
FT                   /id="PRO_0000200173"
FT   DNA_BIND        20..79
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           5..10
FT                   /note="Antp-type hexapeptide"
FT   NON_TER         1
SQ   SEQUENCE   87 AA;  11058 MW;  E67939E334E2BA43 CRC64;
     EFRQIYPWMT KLHMSHETDG KRSRTSYTRY QTLELEKEFH FNRYLTRRRR IEIANNLCLN
     ERQIKIWFQN RRMKWKKDTK VKSKDSM