HXC6A_DANRE
ID HXC6A_DANRE Reviewed; 231 AA.
AC P15862; Q4PR89; Q5XJJ4; Q6LAJ7; Q9PWM4;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Homeobox protein Hox-C6a;
DE Short=Hox-C6;
DE AltName: Full=Homeobox protein Zf-61;
GN Name=hoxc6a; Synonyms=hox-c6, hoxc6, zf61; ORFNames=zgc:101882;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-231.
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 40-147.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-231.
RX PubMed=1968004; DOI=10.1002/j.1460-2075.1990.tb08138.x;
RA Njolstad P.R., Molven A., Apold J., Fjose A.;
RT "The zebrafish homeobox gene hox-2.2: transcription unit, potential
RT regulatory regions and in situ localization of transcripts.";
RL EMBO J. 9:515-524(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 143-231, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT "Differences in expression pattern and function between zebrafish hoxc13
RT orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL Dev. Biol. 274:318-333(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, from
CC ova through to 48 hours post-fertilization. At the 10-somite stage,
CC expressed in the paraxial mesoderm with an anterior expression limit at
CC somite 5. At the 20-somite stage, expressed in the developing CNS with
CC an anterior expression adjacent to the somite 2/3 boundary.
CC {ECO:0000269|PubMed:15385162, ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH83307.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF071265; AAD15958.1; -; Genomic_DNA.
DR EMBL; BC083307; AAH83307.1; ALT_INIT; mRNA.
DR EMBL; DQ060554; AAY67932.1; -; mRNA.
DR EMBL; X17266; CAA35170.1; -; Genomic_DNA.
DR EMBL; Y14546; CAA74881.1; -; mRNA.
DR PIR; S08639; S08639.
DR RefSeq; NP_571198.1; NM_131123.1.
DR AlphaFoldDB; P15862; -.
DR SMR; P15862; -.
DR STRING; 7955.ENSDARP00000093809; -.
DR PaxDb; P15862; -.
DR PRIDE; P15862; -.
DR DNASU; 30346; -.
DR GeneID; 30346; -.
DR KEGG; dre:30346; -.
DR CTD; 30346; -.
DR ZFIN; ZDB-GENE-990415-113; hoxc6a.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P15862; -.
DR OrthoDB; 1186205at2759; -.
DR PhylomeDB; P15862; -.
DR TreeFam; TF316310; -.
DR PRO; PR:P15862; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..231
FT /note="Homeobox protein Hox-C6a"
FT /id="PRO_0000200177"
FT DNA_BIND 142..201
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 200..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 123..128
FT /note="Antp-type hexapeptide"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 26733 MW; 65164A13541D7E8A CRC64;
MNSYFANPSL SCHLSGGQEV LPNMPLNSTT YDSVRHFSSY GTTVTQNRIY ASPFYSPQDN
VVFGSSRGPY EYGSNVFLQD KDVLPSCRQT SMGLNAQSHV AQEYNLEQAR AGTQDQKANN
IQIYPWMQRM NSHSGVGYGS DRRRGRQIYS RYQTLELEKE FHFNRYLTRR RRIEIANALC
LTERQIKIWF QNRRMKWKKE TNLTSTVPGT ESAGTPQETE KETEEEPKKK D
