HXC6A_TAKRU
ID HXC6A_TAKRU Reviewed; 236 AA.
AC O42504;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Homeobox protein Hox-C6a;
DE AltName: Full=FrHOXC-6;
GN Name=hoxc6a; Synonyms=hoxc6;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9140399; DOI=10.1038/ng0597-79;
RA Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B.,
RA Chen E., Krumlauf R., Brenner S.;
RT "Organization of the Fugu rubripes Hox clusters: evidence for continuing
RT evolution of vertebrate Hox complexes.";
RL Nat. Genet. 16:79-83(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT regulatory elements within and outside Hox gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; U92572; AAB68682.1; -; Genomic_DNA.
DR EMBL; DQ481667; ABF22446.1; -; Genomic_DNA.
DR RefSeq; XP_003963113.1; XM_003963064.2.
DR AlphaFoldDB; O42504; -.
DR SMR; O42504; -.
DR STRING; 31033.ENSTRUP00000008754; -.
DR Ensembl; ENSTRUT00000008805; ENSTRUP00000008754; ENSTRUG00000022036.
DR GeneID; 101078451; -.
DR KEGG; tru:101078451; -.
DR CTD; 30346; -.
DR eggNOG; KOG0487; Eukaryota.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159254; -.
DR InParanoid; O42504; -.
DR OrthoDB; 1186205at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..236
FT /note="Homeobox protein Hox-C6a"
FT /id="PRO_0000265988"
FT DNA_BIND 140..199
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 198..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 121..126
FT /note="Antp-type hexapeptide"
FT COMPBIAS 213..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 27181 MW; AC203E8AF4F09619 CRC64;
MNSYFANPSL SCHLSGGQDV LPNVPLNSTT YDTVRHFSSY GAAVTQNRIY APFYSPQDNV
VFGSGRAQYD YGSNVFLQDK DVLPSCRQTN MGLSTQSHIA QEYSLDQGRT GTQEQKSNIP
IYPWMQRMNS HSGVGYGTDR RRGRQIYSRY QTLELEKEFH FNRYLTRRRR IEIANALCLT
ERQIKIWFQN RRMKWKKESN LTSTVTGSEQ TGGSQEERED RGGATEEGKD EDKKKE
