HXC6B_DANRE
ID HXC6B_DANRE Reviewed; 227 AA.
AC Q9PWM5; O57377; Q4PR82;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Homeobox protein Hox-C6b;
GN Name=hoxc6b; Synonyms=hoxy6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-143.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 136-227, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT "Differences in expression pattern and function between zebrafish hoxc13
RT orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL Dev. Biol. 274:318-333(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, from
CC ova through to 48 hours post-fertilization. At the 10-somite stage,
CC expressed in the paraxial mesoderm with an anterior expression limit at
CC somite 5. At the 20-somite stage, expressed in the developing CNS with
CC an anterior expression adjacent to the somite 3/4 boundary.
CC {ECO:0000269|PubMed:15385162, ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AF071266; AAD15959.1; -; Genomic_DNA.
DR EMBL; DQ060561; AAY67939.1; -; mRNA.
DR EMBL; Y14537; CAA74872.1; -; mRNA.
DR AlphaFoldDB; Q9PWM5; -.
DR SMR; Q9PWM5; -.
DR STRING; 7955.ENSDARP00000067697; -.
DR PaxDb; Q9PWM5; -.
DR ZFIN; ZDB-GENE-000822-1; hoxc6b.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; Q9PWM5; -.
DR PRO; PR:Q9PWM5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..227
FT /note="Homeobox protein Hox-C6b"
FT /id="PRO_0000200178"
FT DNA_BIND 135..194
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 200..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 117..122
FT /note="Antp-type hexapeptide"
FT COMPBIAS 212..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 109
FT /note="V -> M (in Ref. 2; AAY67939)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="V -> S (in Ref. 2; AAY67939)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="R -> SG (in Ref. 2; AAY67939)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="R -> Q (in Ref. 2; AAY67939)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 26359 MW; 3CBFC3AC42966C26 CRC64;
MNSYFTNPSL SCHLNSGQEV LPSVAISSTN YDPVRHFSPY GAAVAQNRIY SNPFYSHQEN
VMFGSSRPYD YGSNMFYQDK DVLPSCRQGF GQTQGSLTQD YASDQGKTVE PKGVVQIYPW
MQRMNSHRVG YGSDRRRGRQ IYSRYQTLEL EKEFHYNRYL TRRRRIEIAN TLCLSERQIK
IWFQNRRMKW KKESNLTSIL NDNGSVGAGQ DTDKEETGET AEKDEHD
