HXC6_MOUSE
ID HXC6_MOUSE Reviewed; 235 AA.
AC P10629; Q61683;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Homeobox protein Hox-C6;
DE AltName: Full=Homeobox protein Hox-3.3;
DE AltName: Full=Homeobox protein Hox-6.1;
GN Name=Hoxc6; Synonyms=Hox-3.3, Hoxc-6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7905473;
RA Shimeld S.M., Gaunt S.J., Coletta P.L., Geada A.M., Sharpe P.T.;
RT "Spatial localisation of transcripts of the Hox-C6 gene.";
RL J. Anat. 183:515-523(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1684715; DOI=10.1016/0925-4773(91)90063-c;
RA Coletta P.L., Shimeld S.M., Chaudhuri C., Mueller U., Clarke J.P.,
RA Sharpe P.T.;
RT "Characterisation of the murine Hox-3.3 gene and its promoter.";
RL Mech. Dev. 35:129-142(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-235.
RC TISSUE=Bone marrow, and Spleen;
RX PubMed=2901346; DOI=10.1002/j.1460-2075.1988.tb03052.x;
RA Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
RT "Expression of multiple homeobox genes within diverse mammalian
RT haemopoietic lineages.";
RL EMBO J. 7:2131-2138(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-235.
RC TISSUE=Kidney;
RX PubMed=2458223; DOI=10.1242/dev.102.2.397;
RA Sharpe P.T., Miller J.R., Evans E.P., Burtenshaw M.D., Gaunt S.J.;
RT "Isolation and expression of a new mouse homeobox gene.";
RL Development 102:397-407(1988).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 133-235.
RX PubMed=2570032; DOI=10.1016/0888-7543(89)90089-x;
RA Schughart K., Pravtcheva D., Newman M.S., Hunihan L.W., Jiang Z.,
RA Ruddle F.H.;
RT "Isolation and regional localization of the murine homeobox-containing gene
RT Hox-3.3 to mouse chromosome region 15E.";
RL Genomics 5:76-83(1989).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=PRII;
CC IsoId=P10629-1; Sequence=Displayed;
CC Name=PRI;
CC IsoId=P10629-2; Sequence=VSP_002393;
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; J03074; AAA37832.1; -; mRNA.
DR EMBL; M35986; AAA37854.1; -; mRNA.
DR EMBL; X16511; CAA34518.1; -; mRNA.
DR EMBL; X16510; CAA34517.1; -; mRNA.
DR EMBL; S74185; AAB20717.1; -; Unassigned_DNA.
DR EMBL; X12504; CAA31022.1; -; mRNA.
DR EMBL; X12504; CAA31023.1; -; mRNA.
DR EMBL; X16838; CAA34737.1; -; mRNA.
DR CCDS; CCDS27895.1; -. [P10629-1]
DR PIR; A32167; A32167.
DR PIR; A56568; A56568.
DR PIR; S00987; WJMSX6.
DR RefSeq; NP_034595.2; NM_010465.2. [P10629-1]
DR RefSeq; XP_006520532.1; XM_006520469.2. [P10629-2]
DR AlphaFoldDB; P10629; -.
DR SMR; P10629; -.
DR BioGRID; 200388; 1.
DR IntAct; P10629; 1.
DR STRING; 10090.ENSMUSP00000001711; -.
DR iPTMnet; P10629; -.
DR PhosphoSitePlus; P10629; -.
DR MaxQB; P10629; -.
DR PaxDb; P10629; -.
DR PRIDE; P10629; -.
DR ProteomicsDB; 267023; -. [P10629-1]
DR ProteomicsDB; 267024; -. [P10629-2]
DR Antibodypedia; 15318; 255 antibodies from 31 providers.
DR DNASU; 15425; -.
DR Ensembl; ENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661. [P10629-1]
DR GeneID; 15425; -.
DR KEGG; mmu:15425; -.
DR UCSC; uc007xxc.1; mouse. [P10629-1]
DR CTD; 3223; -.
DR MGI; MGI:96197; Hoxc6.
DR VEuPathDB; HostDB:ENSMUSG00000001661; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159254; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P10629; -.
DR OMA; CHLTGGQ; -.
DR OrthoDB; 1186205at2759; -.
DR PhylomeDB; P10629; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15425; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Hoxc6; mouse.
DR PRO; PR:P10629; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P10629; protein.
DR Bgee; ENSMUSG00000001661; Expressed in embryonic post-anal tail and 96 other tissues.
DR ExpressionAtlas; P10629; baseline and differential.
DR Genevisible; P10629; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..235
FT /note="Homeobox protein Hox-C6"
FT /id="PRO_0000200175"
FT DNA_BIND 141..200
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 200..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 122..127
FT /note="Antp-type hexapeptide"
FT COMPBIAS 218..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..82
FT /note="Missing (in isoform PRI)"
FT /evidence="ECO:0000305"
FT /id="VSP_002393"
FT CONFLICT 15..18
FT /note="AGGQ -> QQRP (in Ref. 3; CAA31022)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="S -> N (in Ref. 4; AAA37854/CAA34737)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="R -> A (in Ref. 4; AAA37854/CAA34737)"
FT /evidence="ECO:0000305"
FT CONFLICT 228..229
FT /note="TE -> QK (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 26915 MW; BD695C7347CB71C0 CRC64;
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
