ID   HXC6_NOTVI              Reviewed;         234 AA.
AC   P14858; P14857;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Homeobox protein Hox-C6;
DE   AltName: Full=FH-2;
DE   AltName: Full=NvHox-1;
GN   Name=HOXC6; Synonyms=NVHOX1;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2907476; DOI=10.1002/j.1460-2075.1988.tb03325.x;
RA   Savard P., Gates P.B., Brockes J.P.;
RT   "Position dependent expression of a homeobox gene transcript in relation to
RT   amphibian limb regeneration.";
RL   EMBO J. 7:4275-4282(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 131-234.
RX   PubMed=2574663; DOI=10.1242/dev.105.4.813;
RA   Tabin C.J.;
RT   "Isolation of potential vertebrate limb-identity genes.";
RL   Development 105:813-820(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X13957; CAA32139.1; -; mRNA.
DR   EMBL; X16848; CAA34745.1; -; mRNA.
DR   PIR; S02014; S02014.
DR   AlphaFoldDB; P14858; -.
DR   SMR; P14858; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..234
FT                   /note="Homeobox protein Hox-C6"
FT                   /id="PRO_0000200179"
FT   DNA_BIND        141..200
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          200..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           122..127
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        217..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   234 AA;  26902 MW;  EA15EED91ED294B0 CRC64;
     MNSYFTNPSL SCHLASGQEV LPNVALNSSA YDPVRHFSTY GEAVAQNRIY SSPFYSPQDN
     VVFSSGRGPY EYGSNAFYQD KDMLSSCRQN AMGHNTQTSI AQDFSSDQSR ASVQEQKTSI
     QIYPWMQRMN SHSGVGYGTD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANASCL
     TERQIKIWFQ NRRMKWKKES NLTSTLSGGT GAASDSLAEG KEKEEETEEE QQKE