ID   HXC6_SHEEP              Reviewed;         153 AA.
AC   P49925;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Homeobox protein Hox-C6;
GN   Name=HOXC6;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cosby N.C., Hernandez-Ledezma J., Mathialagan N., Roberts R.;
RT   "Identification of an Antennapedia-type homeotic factor in the
RT   preimplantation ruminant conceptus.";
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U33049; AAA75473.1; -; mRNA.
DR   RefSeq; NP_001009335.1; NM_001009335.1.
DR   AlphaFoldDB; P49925; -.
DR   SMR; P49925; -.
DR   STRING; 9940.ENSOARP00000017496; -.
DR   PRIDE; P49925; -.
DR   GeneID; 443349; -.
DR   KEGG; oas:443349; -.
DR   CTD; 3223; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   OrthoDB; 1186205at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Homeobox protein Hox-C6"
FT                   /id="PRO_0000200176"
FT   DNA_BIND        59..118
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           40..45
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        136..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   153 AA;  17804 MW;  291E24399159621E CRC64;
     MLSNCRQNTL GHNTQTSIAQ DFSSEQGRTA PQDQKASIQI YPWMQRMNSH SGVGYGADRR
     RGRQIYSRYQ TLELEKEFHF NRYLTRRRRI EIANALCLTE RQIKIWFQNR RMKWKKESNL
     TSTLSGGGGG AAADSLGGKE EKREETEEEK QKE