ID   HXC6_XENLA              Reviewed;         234 AA.
AC   P02832; Q5XGV9;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Homeobox protein Hox-C6;
DE   AltName: Full=AC1;
DE   AltName: Full=XlHbox-1;
GN   Name=hoxc6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=2901347; DOI=10.1002/j.1460-2075.1988.tb03053.x;
RA   Cho K.W.Y., Goetz J., Wright C.V.E., Fritz A., Hardwicke J.,
RA   De Robertis E.M.;
RT   "Differential utilization of the same reading frame in a Xenopus homeobox
RT   gene encodes two related proteins sharing the same DNA-binding
RT   specificity.";
RL   EMBO J. 7:2139-2149(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 121-234.
RX   PubMed=2894634; DOI=10.1093/nar/16.4.1453;
RA   Fritz A., De Robertis E.M.;
RT   "Xenopus homeobox-containing cDNAs expressed in early development.";
RL   Nucleic Acids Res. 16:1453-1469(1988).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-200.
RX   PubMed=6327066; DOI=10.1016/0092-8674(84)90371-4;
RA   Carrasco A.E., McGinnis W., Gehring W.J., De Robertis E.M.;
RT   "Cloning of an X. laevis gene expressed during early embryogenesis coding
RT   for a peptide region homologous to Drosophila homeotic genes.";
RL   Cell 37:409-414(1984).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=1; Synonyms=Hox-C6 PRII;
CC         IsoId=P02832-1; Sequence=Displayed;
CC       Name=2; Synonyms=Hox-C6 PRI;
CC         IsoId=P02832-2; Sequence=VSP_021567;
CC   -!- DEVELOPMENTAL STAGE: Expressed exclusively in early Xenopus embryos.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X12499; CAA31020.1; -; mRNA.
DR   EMBL; X12500; CAA31021.1; -; mRNA.
DR   EMBL; BC084319; AAH84319.1; -; mRNA.
DR   EMBL; X07101; CAA30122.1; -; mRNA.
DR   EMBL; K01943; AAA49743.1; -; Genomic_DNA.
DR   PIR; S00992; S00992.
DR   RefSeq; NP_001081015.1; NM_001087546.1. [P02832-1]
DR   AlphaFoldDB; P02832; -.
DR   SMR; P02832; -.
DR   DNASU; 394330; -.
DR   GeneID; 394330; -.
DR   KEGG; xla:394330; -.
DR   CTD; 394330; -.
DR   Xenbase; XB-GENE-865143; hoxc6.S.
DR   OMA; TRGPYEY; -.
DR   OrthoDB; 1186205at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 394330; Expressed in neurula embryo and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative initiation; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="Homeobox protein Hox-C6"
FT                   /id="PRO_0000013498"
FT   DNA_BIND        141..200
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          88..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           122..127
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        217..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..82
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:2901347"
FT                   /id="VSP_021567"
FT   VARIANT         139
FT                   /note="T -> S"
SQ   SEQUENCE   234 AA;  26689 MW;  4C371CC5252D2C58 CRC64;
     MNSYFTNPSL SCHLASGQEV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY SSPFYTPQDN
     VVFGSSRGPY EYGSNAFYQD KDMLTSCRQN SMGHNTQSSL AQDFSSEQNR GNGQEQKGSI
     QIYPWMQRMN SHSGVGYGTD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
     TERQIKIWFQ NRRMKWKKES NLSSTLPGGT GAAADSLAEG KEEKQEDSEG QGKE