HXC8A_DANRE
ID HXC8A_DANRE Reviewed; 250 AA.
AC Q68EH7; A2BE64; O57369; Q4PR88;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Homeobox protein Hox-C8a;
GN Name=hoxc8a {ECO:0000312|EMBL:AAY67933.1};
GN Synonyms=hoxc8 {ECO:0000312|EMBL:CAA74879.1};
GN ORFNames=si:dkey-81p22.5, zgc:91832;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:AAH80255.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAY67933.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 55-157.
RC STRAIN=Tuebingen {ECO:0000269|PubMed:16174031};
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4] {ECO:0000305, ECO:0000312|EMBL:CAA74879.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 177-250, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:9425136};
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000250|UniProtKB:P31273}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P31273,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: At the 10-somite stage, expressed in the paraxial
CC mesoderm with an anterior expression limit at somite 7. At the 20-
CC somite stage, expressed in the developing CNS with an anterior
CC expression limit adjacent to somite 4. {ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000255}.
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DR EMBL; BX005254; CAM16418.1; -; Genomic_DNA.
DR EMBL; BC080255; AAH80255.1; -; mRNA.
DR EMBL; DQ060555; AAY67933.1; -; mRNA.
DR EMBL; Y14544; CAA74879.1; -; mRNA.
DR RefSeq; NP_001005771.1; NM_001005771.1.
DR AlphaFoldDB; Q68EH7; -.
DR SMR; Q68EH7; -.
DR STRING; 7955.ENSDARP00000093913; -.
DR PaxDb; Q68EH7; -.
DR Ensembl; ENSDART00000103139; ENSDARP00000093913; ENSDARG00000070346.
DR GeneID; 449648; -.
DR KEGG; dre:449648; -.
DR CTD; 449648; -.
DR ZFIN; ZDB-GENE-990415-114; hoxc8a.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161194; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; Q68EH7; -.
DR OMA; GFQHPTH; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; Q68EH7; -.
DR TreeFam; TF316310; -.
DR PRO; PR:Q68EH7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000070346; Expressed in swim bladder and 48 other tissues.
DR ExpressionAtlas; Q68EH7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IGI:ZFIN.
DR GO; GO:0031018; P:endocrine pancreas development; IGI:ZFIN.
DR GO; GO:0031017; P:exocrine pancreas development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..250
FT /note="Homeobox protein Hox-C8a"
FT /id="PRO_0000248835"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 112..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 138..143
FT /note="Antp-type hexapeptide"
FT /evidence="ECO:0000255"
FT COMPBIAS 112..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 250 AA; 28616 MW; E10712DA039D7197 CRC64;
MSSYFVNPLF SKYKGGETLE PTYYDCRFPQ SVARSHTLVY GHGAAAPGFQ HPSHHVQDFF
HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQPLY GTQQEATLAQ YPDCKSSNST
NPGEGQGHLS QNSSPSLMFP WMRPHAPGRR NGRQTYSRYQ TLELEKEFLF NPYLTRKRRI
EVSHALSLTE RQVKIWFQNR RMKWKKENNK DKFPGQRGEA EAEAEEEGNE DGEAEEGEDK
ETEEKEESKE
