ID   HXC8A_TAKRU             Reviewed;         392 AA.
AC   O42503;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Homeobox protein Hox-C8a;
DE   AltName: Full=FrHOXC-8;
GN   Name=hoxc8a; Synonyms=hoxc8;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9140399; DOI=10.1038/ng0597-79;
RA   Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B.,
RA   Chen E., Krumlauf R., Brenner S.;
RT   "Organization of the Fugu rubripes Hox clusters: evidence for continuing
RT   evolution of vertebrate Hox complexes.";
RL   Nat. Genet. 16:79-83(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U92572; AAB68681.1; -; Genomic_DNA.
DR   EMBL; DQ481667; ABF22445.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42503; -.
DR   SMR; O42503; -.
DR   PRIDE; O42503; -.
DR   InParanoid; O42503; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Homeobox protein Hox-C8a"
FT                   /id="PRO_0000265989"
FT   DNA_BIND        225..284
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          290..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           138..143
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        293..321
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  45427 MW;  A45B1D64485D93E4 CRC64;
     MSSYFVNPLF SKYKGGESLE PTYYDCRFPQ SVARSHTLVY GPGGAAPGFQ HPSHHVQDFF
     HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQTLY GTQQDASLAQ YPDCKSSSSS
     NPGEGQGHLN QNSSPSLMFP WMRPHGQNNT VISYIFSPMF LCVRAYVRVC VCMSVFVCVL
     KCCLSARVSL TYKMKLVREH DGAHRTCTAG CCCSAAHVHT GLDGRRNGRQ TYSRYQTLEL
     EKEFLFNPYL TRKRRIEVSH ALSLTERQVK IWFQNRRMKW KKENNKTSFR VRGERLKPRK
     RATRTVKGKR RKRKKRKRKR RPRSDFMVLF MVIWLKGRKK EWPHKQMKSH KESESVNFMT
     ILSFFFCREE NRNPTNVAVI NRQKKSSTFI LT