HXC8_HUMAN
ID HXC8_HUMAN Reviewed; 242 AA.
AC P31273; A8K4J4; O15221; O15362;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 200.
DE RecName: Full=Homeobox protein Hox-C8;
DE AltName: Full=Homeobox protein Hox-3A;
GN Name=HOXC8; Synonyms=HOX3A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11857506; DOI=10.1002/tera.10009;
RA Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA Tomita M., McGinnis W., Matsuo N.;
RT "Complete mutation analysis panel of the 39 human HOX genes.";
RL Teratology 65:50-62(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 64-114 AND 147-195.
RX PubMed=9357979; DOI=10.1016/s0014-5793(97)01118-6;
RA Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.;
RT "Distinct patterns of all-trans retinoic acid dependent expression of HOXB
RT and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell
RT lines.";
RL FEBS Lett. 415:263-267(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-214.
RX PubMed=2576652; DOI=10.1139/g89-133;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
RN [7]
RP INTERACTION WITH PBX1.
RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT products of multiple murine Hox genes, some of which are themselves
RT oncogenes.";
RL Mol. Cell. Biol. 15:3786-3795(1995).
RN [8]
RP INTERACTION WITH HOMEZ.
RX PubMed=12925734; DOI=10.1073/pnas.1834010100;
RA Bayarsaihan D., Enkhmandakh B., Makeyev A., Greally J.M., Leckman J.F.,
RA Ruddle F.H.;
RT "Homez, a homeobox leucine zipper gene specific to the vertebrate
RT lineage.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10358-10363(2003).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Interacts with HOMEZ (PubMed:12925734). Forms a DNA-binding
CC heterodimer with transcription factor PBX1 (PubMed:7791786).
CC {ECO:0000269|PubMed:12925734, ECO:0000269|PubMed:7791786}.
CC -!- INTERACTION:
CC P31273; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-1752118, EBI-10173507;
CC P31273; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-1752118, EBI-11954519;
CC P31273; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-1752118, EBI-2548012;
CC P31273; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-1752118, EBI-718615;
CC P31273; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-1752118, EBI-11976299;
CC P31273; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-1752118, EBI-8643161;
CC P31273; A2RRN7: CADPS; NbExp=3; IntAct=EBI-1752118, EBI-10179719;
CC P31273; Q9BSQ5: CCM2; NbExp=3; IntAct=EBI-1752118, EBI-1573056;
CC P31273; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-1752118, EBI-739624;
CC P31273; P05813: CRYBA1; NbExp=3; IntAct=EBI-1752118, EBI-7043337;
CC P31273; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1752118, EBI-3867333;
CC P31273; Q92997: DVL3; NbExp=3; IntAct=EBI-1752118, EBI-739789;
CC P31273; Q86Y13: DZIP3; NbExp=3; IntAct=EBI-1752118, EBI-948630;
CC P31273; Q16610: ECM1; NbExp=3; IntAct=EBI-1752118, EBI-947964;
CC P31273; P49356: FNTB; NbExp=3; IntAct=EBI-1752118, EBI-602349;
CC P31273; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1752118, EBI-5916454;
CC P31273; Q9H4Y5: GSTO2; NbExp=3; IntAct=EBI-1752118, EBI-10194609;
CC P31273; P13807: GYS1; NbExp=3; IntAct=EBI-1752118, EBI-740553;
CC P31273; Q9UBX0: HESX1; NbExp=3; IntAct=EBI-1752118, EBI-8470369;
CC P31273; P31249: HOXD3; NbExp=3; IntAct=EBI-1752118, EBI-3957655;
CC P31273; O75031: HSF2BP; NbExp=3; IntAct=EBI-1752118, EBI-7116203;
CC P31273; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-1752118, EBI-747204;
CC P31273; Q7L273: KCTD9; NbExp=3; IntAct=EBI-1752118, EBI-4397613;
CC P31273; Q5T749: KPRP; NbExp=3; IntAct=EBI-1752118, EBI-10981970;
CC P31273; O76011: KRT34; NbExp=5; IntAct=EBI-1752118, EBI-1047093;
CC P31273; Q92764: KRT35; NbExp=3; IntAct=EBI-1752118, EBI-1058674;
CC P31273; O76013-2: KRT36; NbExp=3; IntAct=EBI-1752118, EBI-11958506;
CC P31273; Q6A162: KRT40; NbExp=3; IntAct=EBI-1752118, EBI-10171697;
CC P31273; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-1752118, EBI-11959885;
CC P31273; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-1752118, EBI-11749135;
CC P31273; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-1752118, EBI-10172290;
CC P31273; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-1752118, EBI-10171774;
CC P31273; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-1752118, EBI-10172052;
CC P31273; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-1752118, EBI-1052037;
CC P31273; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-1752118, EBI-10210845;
CC P31273; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-1752118, EBI-10241252;
CC P31273; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-1752118, EBI-12196745;
CC P31273; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-1752118, EBI-12111050;
CC P31273; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-1752118, EBI-11962084;
CC P31273; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-1752118, EBI-10261141;
CC P31273; Q5SW96: LDLRAP1; NbExp=8; IntAct=EBI-1752118, EBI-747813;
CC P31273; O95751: LDOC1; NbExp=3; IntAct=EBI-1752118, EBI-740738;
CC P31273; P50458: LHX2; NbExp=3; IntAct=EBI-1752118, EBI-12179869;
CC P31273; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-1752118, EBI-12039345;
CC P31273; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-1752118, EBI-18273118;
CC P31273; Q13387-4: MAPK8IP2; NbExp=3; IntAct=EBI-1752118, EBI-12345753;
CC P31273; P50221: MEOX1; NbExp=3; IntAct=EBI-1752118, EBI-2864512;
CC P31273; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1752118, EBI-16439278;
CC P31273; A6NJ78-4: METTL15; NbExp=3; IntAct=EBI-1752118, EBI-10174029;
CC P31273; Q6IA69: NADSYN1; NbExp=3; IntAct=EBI-1752118, EBI-748610;
CC P31273; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-1752118, EBI-10271199;
CC P31273; Q8IV28: NID2; NbExp=3; IntAct=EBI-1752118, EBI-10261509;
CC P31273; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-1752118, EBI-22310682;
CC P31273; O43482: OIP5; NbExp=3; IntAct=EBI-1752118, EBI-536879;
CC P31273; Q02548: PAX5; NbExp=3; IntAct=EBI-1752118, EBI-296331;
CC P31273; P26367: PAX6; NbExp=3; IntAct=EBI-1752118, EBI-747278;
CC P31273; Q06710: PAX8; NbExp=3; IntAct=EBI-1752118, EBI-2683132;
CC P31273; P40424: PBX1; NbExp=3; IntAct=EBI-1752118, EBI-301611;
CC P31273; P40425: PBX2; NbExp=3; IntAct=EBI-1752118, EBI-348489;
CC P31273; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-1752118, EBI-10302990;
CC P31273; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-1752118, EBI-9640281;
CC P31273; Q99471: PFDN5; NbExp=3; IntAct=EBI-1752118, EBI-357275;
CC P31273; O15496: PLA2G10; NbExp=3; IntAct=EBI-1752118, EBI-726466;
CC P31273; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-1752118, EBI-949255;
CC P31273; Q16633: POU2AF1; NbExp=3; IntAct=EBI-1752118, EBI-943588;
CC P31273; P78424: POU6F2; NbExp=3; IntAct=EBI-1752118, EBI-12029004;
CC P31273; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-1752118, EBI-3957793;
CC P31273; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-1752118, EBI-11320284;
CC P31273; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-1752118, EBI-2340624;
CC P31273; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-1752118, EBI-10269374;
CC P31273; Q15036: SNX17; NbExp=8; IntAct=EBI-1752118, EBI-1752620;
CC P31273; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-1752118, EBI-1644036;
CC P31273; O60806: TBX19; NbExp=3; IntAct=EBI-1752118, EBI-12096770;
CC P31273; Q9Y458: TBX22; NbExp=3; IntAct=EBI-1752118, EBI-6427217;
CC P31273; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-1752118, EBI-750487;
CC P31273; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1752118, EBI-11741437;
CC P31273; Q63HR2: TNS2; NbExp=3; IntAct=EBI-1752118, EBI-949753;
CC P31273; Q13077: TRAF1; NbExp=3; IntAct=EBI-1752118, EBI-359224;
CC P31273; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-1752118, EBI-492476;
CC P31273; P14373: TRIM27; NbExp=3; IntAct=EBI-1752118, EBI-719493;
CC P31273; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-1752118, EBI-5235829;
CC P31273; Q15654: TRIP6; NbExp=3; IntAct=EBI-1752118, EBI-742327;
CC P31273; Q86WV8: TSC1; NbExp=3; IntAct=EBI-1752118, EBI-12806590;
CC P31273; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-1752118, EBI-11975223;
CC P31273; O95231: VENTX; NbExp=3; IntAct=EBI-1752118, EBI-10191303;
CC P31273; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-1752118, EBI-12040603;
CC P31273; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-1752118, EBI-11419867;
CC P31273; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-1752118, EBI-7850213;
CC P31273; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-1752118, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AY014300; AAG42146.1; -; Genomic_DNA.
DR EMBL; AY014299; AAG42146.1; JOINED; Genomic_DNA.
DR EMBL; AK290959; BAF83648.1; -; mRNA.
DR EMBL; CH471054; EAW96743.1; -; Genomic_DNA.
DR EMBL; BC053898; AAH53898.1; -; mRNA.
DR EMBL; X99680; CAA67996.1; -; mRNA.
DR EMBL; X99681; CAA67997.1; -; mRNA.
DR CCDS; CCDS8870.1; -.
DR PIR; S15534; S15534.
DR RefSeq; NP_073149.1; NM_022658.3.
DR AlphaFoldDB; P31273; -.
DR SMR; P31273; -.
DR BioGRID; 109464; 115.
DR CORUM; P31273; -.
DR DIP; DIP-52312N; -.
DR ELM; P31273; -.
DR IntAct; P31273; 99.
DR MINT; P31273; -.
DR STRING; 9606.ENSP00000040584; -.
DR iPTMnet; P31273; -.
DR PhosphoSitePlus; P31273; -.
DR BioMuta; HOXC8; -.
DR DMDM; 13124745; -.
DR EPD; P31273; -.
DR jPOST; P31273; -.
DR MassIVE; P31273; -.
DR MaxQB; P31273; -.
DR PaxDb; P31273; -.
DR PeptideAtlas; P31273; -.
DR PRIDE; P31273; -.
DR ProteomicsDB; 54773; -.
DR Antibodypedia; 27310; 268 antibodies from 35 providers.
DR DNASU; 3224; -.
DR Ensembl; ENST00000040584.6; ENSP00000040584.4; ENSG00000037965.6.
DR GeneID; 3224; -.
DR KEGG; hsa:3224; -.
DR MANE-Select; ENST00000040584.6; ENSP00000040584.4; NM_022658.4; NP_073149.1.
DR UCSC; uc001ser.4; human.
DR CTD; 3224; -.
DR DisGeNET; 3224; -.
DR GeneCards; HOXC8; -.
DR HGNC; HGNC:5129; HOXC8.
DR HPA; ENSG00000037965; Tissue enhanced (epididymis, skeletal muscle).
DR MIM; 142970; gene.
DR neXtProt; NX_P31273; -.
DR OpenTargets; ENSG00000037965; -.
DR PharmGKB; PA29404; -.
DR VEuPathDB; HostDB:ENSG00000037965; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161194; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; P31273; -.
DR OMA; GFQHPTH; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31273; -.
DR TreeFam; TF316310; -.
DR PathwayCommons; P31273; -.
DR SignaLink; P31273; -.
DR SIGNOR; P31273; -.
DR BioGRID-ORCS; 3224; 8 hits in 1097 CRISPR screens.
DR ChiTaRS; HOXC8; human.
DR GeneWiki; HOXC8; -.
DR GenomeRNAi; 3224; -.
DR Pharos; P31273; Tbio.
DR PRO; PR:P31273; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P31273; protein.
DR Bgee; ENSG00000037965; Expressed in sural nerve and 82 other tissues.
DR Genevisible; P31273; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..242
FT /note="Homeobox protein Hox-C8"
FT /id="PRO_0000200180"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 114..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 138..143
FT /note="Antp-type hexapeptide"
FT COMPBIAS 114..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 165
FT /note="E -> Q (in Ref. 6; CAA67997)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 27755 MW; 30C1FD06228833FC CRC64;
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN
KD
