HXC8_MOUSE
ID HXC8_MOUSE Reviewed; 242 AA.
AC P09025;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Homeobox protein Hox-C8;
DE AltName: Full=Homeobox protein Hox-3.1;
DE AltName: Full=Homeobox protein M31;
GN Name=Hoxc8; Synonyms=Hox-3.1, Hoxc-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2895723; DOI=10.1101/gad.2.1.125;
RA le Mouellic H., Condamine H., Brulet P.;
RT "Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo.";
RL Genes Dev. 2:125-135(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2900757; DOI=10.1002/j.1460-2075.1988.tb02948.x;
RA Breier G., Dressler G.R., Gruss P.;
RT "Primary structure and developmental expression pattern of Hox 3.1, a
RT member of the murine Hox 3 homeobox gene cluster.";
RL EMBO J. 7:1329-1336(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CD-1;
RX PubMed=1696731; DOI=10.1073/pnas.87.16.6428;
RA Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.;
RT "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-
RT 3.1 intergenic region.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216.
RX PubMed=3007994; DOI=10.1038/320328a0;
RA Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.;
RT "Spatial restriction in expression of a mouse homoeo box locus within the
RT central nervous system.";
RL Nature 320:328-335(1986).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 149-215.
RX PubMed=2877873; DOI=10.1002/j.1460-2075.1986.tb04486.x;
RA Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.;
RT "Sequential expression of murine homeo box genes during F9 EC cell
RT differentiation.";
RL EMBO J. 5:2209-2215(1986).
RN [6]
RP INTERACTION WITH PBX1.
RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT products of multiple murine Hox genes, some of which are themselves
RT oncogenes.";
RL Mol. Cell. Biol. 15:3786-3795(1995).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Interacts with HOMEZ (By similarity). Forms a DNA-binding
CC heterodimer with transcription factor PBX1 (PubMed:7791786).
CC {ECO:0000250|UniProtKB:P31273, ECO:0000269|PubMed:7791786}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Initially found in all tissues of the posterior
CC region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically
CC located in neural tissue.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X07439; CAA30319.1; -; mRNA.
DR EMBL; X07646; CAA30486.1; -; mRNA.
DR EMBL; M35603; AAA37857.1; -; Genomic_DNA.
DR EMBL; X03659; CAA27294.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS27894.1; -.
DR PIR; B25180; A25180.
DR PIR; B36023; WJMSX3.
DR PIR; S13785; S13785.
DR RefSeq; NP_034596.1; NM_010466.2.
DR AlphaFoldDB; P09025; -.
DR SMR; P09025; -.
DR BioGRID; 200389; 2.
DR IntAct; P09025; 1.
DR STRING; 10090.ENSMUSP00000001703; -.
DR iPTMnet; P09025; -.
DR PhosphoSitePlus; P09025; -.
DR MaxQB; P09025; -.
DR PaxDb; P09025; -.
DR PRIDE; P09025; -.
DR ProteomicsDB; 267025; -.
DR Antibodypedia; 27310; 268 antibodies from 35 providers.
DR DNASU; 15426; -.
DR Ensembl; ENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
DR GeneID; 15426; -.
DR KEGG; mmu:15426; -.
DR UCSC; uc012aaf.1; mouse.
DR CTD; 3224; -.
DR MGI; MGI:96198; Hoxc8.
DR VEuPathDB; HostDB:ENSMUSG00000001657; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161194; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; P09025; -.
DR OMA; GFQHPTH; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P09025; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15426; 2 hits in 74 CRISPR screens.
DR PRO; PR:P09025; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P09025; protein.
DR Bgee; ENSMUSG00000001657; Expressed in epididymis and 140 other tissues.
DR Genevisible; P09025; MM.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..242
FT /note="Homeobox protein Hox-C8"
FT /id="PRO_0000200181"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 114..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 138..143
FT /note="Antp-type hexapeptide"
FT COMPBIAS 114..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 151
FT /note="S -> T (in Ref. 4; CAA27294)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="E -> Q (in Ref. 4; CAA27294)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 27740 MW; 4A2A53BDA4CFA878 CRC64;
MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN
KD
