ID   HXC8_RAT                Reviewed;         108 AA.
AC   P18866;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Homeobox protein Hox-C8;
DE   AltName: Full=Homeobox protein R4;
DE   Flags: Fragment;
GN   Name=Hoxc8; Synonyms=Hoxc-8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=7702549; DOI=10.1007/bf02426897;
RA   Sakoyama Y., Mizuta I., Ogasawara N., Yoshikawa H.;
RT   "Cloning of rat homeobox genes.";
RL   Biochem. Genet. 32:351-360(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-108.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=2907739; DOI=10.1242/dev.103.3.601;
RA   Falzon M., Chung S.Y.;
RT   "The expression of rat homeobox-containing genes is developmentally
RT   regulated and tissue specific.";
RL   Development 103:601-610(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBUNIT: Interacts with HOMEZ. Forms a DNA-binding heterodimer with
CC       transcription factor PBX1. {ECO:0000250|UniProtKB:P31273}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Predominantly spinal cord and kidney.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; S76301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M37568; AAA41344.1; -; Genomic_DNA.
DR   PIR; D43559; D43559.
DR   AlphaFoldDB; P18866; -.
DR   SMR; P18866; -.
DR   STRING; 10116.ENSRNOP00000035473; -.
DR   PaxDb; P18866; -.
DR   UCSC; RGD:1595784; rat.
DR   RGD; 2821; Hoxc8.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P18866; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048705; P:skeletal system morphogenesis; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..108
FT                   /note="Homeobox protein Hox-C8"
FT                   /id="PRO_0000200182"
FT   DNA_BIND        15..74
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          73..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..102
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   108 AA;  13115 MW;  DBF8C0AD6A0B08E1 CRC64;
     RHNQTGVLFC SAPGRRSGRQ TYSRYQTLEL EKEFLFNPYL TRKRRIEVSH ALGLTERQVK
     IWFQNRRMKW KKENNKDKLP GARDEEKVEE EGNEEEEKEE EEKEENKD