HXC9A_DANRE
ID HXC9A_DANRE Reviewed; 260 AA.
AC Q9YGS6; O57370; Q4PR87; Q4VBV5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Homeobox protein Hox-C9a;
DE Short=Hox-C9;
GN Name=hoxc9a; Synonyms=hoxc9; ORFNames=zgc:109844;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 97-227.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 221-260, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: At the 10-somite stage, expressed in the paraxial
CC mesoderm with an anterior expression limit at somite 8. At the 20-
CC somite stage, expressed in the developing CNS with an anterior
CC expression limit adjacent to the somite 7/8 boundary.
CC {ECO:0000269|PubMed:9425136}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AF071267; AAD15960.1; -; Genomic_DNA.
DR EMBL; BC095014; AAH95014.1; -; mRNA.
DR EMBL; DQ060556; AAY67934.1; -; mRNA.
DR EMBL; Y14540; CAA74875.1; -; mRNA.
DR AlphaFoldDB; Q9YGS6; -.
DR SMR; Q9YGS6; -.
DR STRING; 7955.ENSDARP00000105244; -.
DR PaxDb; Q9YGS6; -.
DR ZFIN; ZDB-GENE-000328-5; hoxc9a.
DR eggNOG; KOG0487; Eukaryota.
DR InParanoid; Q9YGS6; -.
DR PhylomeDB; Q9YGS6; -.
DR PRO; PR:Q9YGS6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:2001213; P:negative regulation of vasculogenesis; IGI:ZFIN.
DR GO; GO:1901492; P:positive regulation of lymphangiogenesis; IMP:ZFIN.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..260
FT /note="Homeobox protein Hox-C9a"
FT /id="PRO_0000200187"
FT DNA_BIND 192..251
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 153..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 40
FT /note="P -> R (in Ref. 1; AAD15960)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="K -> N (in Ref. 4; CAA74875)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29782 MW; 0E134BDA83B23B40 CRC64;
MSATGPISNY YVDSLINHES EDVLASRFTA TGPISSSSRP TPLVPECADY PSCSFAPKPP
VFTTSWAPVH SQSSVVYHPY THQPHLGTDS RYVRSWLEPI PGTVSFPGYA GNSRHYGLKP
DTFQDPRAGD CLGSNGRTYT DYLYCSAVDI REKQQNTPSP ETESLSSGKH KDDKAELDPN
NPVANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF
QNRRMKMKKM NKEKNDSKEQ
