HXC9_MOUSE
ID HXC9_MOUSE Reviewed; 260 AA.
AC P09633;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Homeobox protein Hox-C9;
DE AltName: Full=Homeobox protein Hox-3.2;
GN Name=Hoxc9; Synonyms=Hox-3.2, Hoxc-9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1723949; DOI=10.1242/dev.110.2.629;
RA Erselius J.R., Goulding M.D., Gruss P.;
RT "Structure and expression pattern of the murine Hox-3.2 gene.";
RL Development 110:629-642(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 187-260.
RX PubMed=2900757; DOI=10.1002/j.1460-2075.1988.tb02948.x;
RA Breier G., Dressler G.R., Gruss P.;
RT "Primary structure and developmental expression pattern of Hox 3.1, a
RT member of the murine Hox 3 homeobox gene cluster.";
RL EMBO J. 7:1329-1336(1988).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-260.
RC STRAIN=CD-1;
RX PubMed=1696731; DOI=10.1073/pnas.87.16.6428;
RA Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.;
RT "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-
RT 3.1 intergenic region.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Interacts with Geminin/GMNN, which inhibits transcriptional
CC activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; X55318; CAA39026.1; -; mRNA.
DR EMBL; AK012173; BAB28077.1; -; mRNA.
DR EMBL; AK078758; BAC37378.1; -; mRNA.
DR EMBL; BC050838; AAH50838.1; -; mRNA.
DR EMBL; X07647; CAA30487.1; -; mRNA.
DR EMBL; M35603; AAA37856.1; -; Genomic_DNA.
DR CCDS; CCDS27893.1; -.
DR PIR; A43821; A43821.
DR RefSeq; NP_032298.1; NM_008272.3.
DR AlphaFoldDB; P09633; -.
DR BMRB; P09633; -.
DR SMR; P09633; -.
DR BioGRID; 200390; 2.
DR IntAct; P09633; 1.
DR STRING; 10090.ENSMUSP00000001706; -.
DR iPTMnet; P09633; -.
DR PhosphoSitePlus; P09633; -.
DR MaxQB; P09633; -.
DR PaxDb; P09633; -.
DR PRIDE; P09633; -.
DR ProteomicsDB; 273329; -.
DR Antibodypedia; 15314; 222 antibodies from 26 providers.
DR DNASU; 15427; -.
DR Ensembl; ENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139.
DR GeneID; 15427; -.
DR KEGG; mmu:15427; -.
DR UCSC; uc007xxa.1; mouse.
DR CTD; 3225; -.
DR MGI; MGI:96199; Hoxc9.
DR VEuPathDB; HostDB:ENSMUSG00000036139; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000160866; -.
DR HOGENOM; CLU_071854_2_0_1; -.
DR InParanoid; P09633; -.
DR OMA; ADYMYAA; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P09633; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 15427; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Hoxc9; mouse.
DR PRO; PR:P09633; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P09633; protein.
DR Bgee; ENSMUSG00000036139; Expressed in embryonic post-anal tail and 93 other tissues.
DR Genevisible; P09633; MM.
DR GO; GO:0016235; C:aggresome; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0017053; C:transcription repressor complex; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..260
FT /note="Homeobox protein Hox-C9"
FT /id="PRO_0000200185"
FT DNA_BIND 192..251
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 120..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P31274"
SQ SEQUENCE 260 AA; 29234 MW; 0A978FF948F5BCAE CRC64;
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF PSCSFAPKPA
VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL SGAVSFPSFP AGGRHYALKP
DAYPGRRADC GPGDGRSYPD YMYGSPGELR DRAPQTLPSP EADALAGSKH KEEKADLDPS
NPVANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF
QNRRMKMKKM NKEKTDKEQS
