ID   HXCAA_TAKRU             Reviewed;         346 AA.
AC   Q1KKV1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Homeobox protein Hox-C10a;
GN   Name=hoxc10a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481667; ABF22443.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1KKV1; -.
DR   SMR; Q1KKV1; -.
DR   PRIDE; Q1KKV1; -.
DR   InParanoid; Q1KKV1; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..346
FT                   /note="Homeobox protein Hox-C10a"
FT                   /id="PRO_0000265990"
FT   DNA_BIND        272..331
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          199..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  39216 MW;  F41D022E743518EA CRC64;
     MSCPNNSGNF LMDPLMGGSS SFRDEGYSSN SGMYIHTAAE CGYSVMKVEP SPLSKSRDVP
     AGSVLLSSFQ DAPYLSAQPS TWTPGTKSSR DQQLVAQCLQ PCSFPAGNVK EEAFCCFYQD
     GSKRKQTTES ATYIRLRDNR CGPEQTTTQA RGCFQMYNRE EPQQDDQLFA PACSLLHLGT
     SVESQSKISC SKFATETGKD ERKEEKARSD GCSETSDNEE LKGRNLQSQR TLFLCLNVSA
     ILLRNSRVLV FGNSHDASSE KTTGNWLKAK SGRKKRCPYT KHQTLELEKE FLFNMYLSRE
     RRLEISRSIN LTDRQVKIWF QNRRMKLKKL NRESREREQG VVYNYC